Diagnosis and Management of Malignant Salivary Gland Tumors of the Parotid Gland

被引：132

作者：

Lewis, Aaron G. ^{[1
]}

Tong, Tommy ^{[2
]}

Maghami, Ellie ^{[3
]}

机构：

[1] City Hope Natl Med Ctr, Dept Surg, 1500 E Duarte Rd, Duarte, CA 91010 USA

[2] City Hope Natl Med Ctr, Dept Pathol, 1500 E Duarte Rd, Duarte, CA 91010 USA

[3] City Hope Natl Med Ctr, Div Head & Neck Surg, 1500 E Duarte Rd, Duarte, CA 91010 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2016年 / 49卷 / 02期

关键词：

Parotid cancer; Malignant salivary cancers; Surgery for parotid salivary cancer; Radiation therapy for parotid cancers; Chemotherapy for parotid tumors; Molecular diagnostics; Genetic translocations of parotid tumors; Molecular targeted therapies; ADENOID CYSTIC CARCINOMA; GROWTH-FACTOR RECEPTOR; ANALOG SECRETORY CARCINOMA; LYMPH-NODE METASTASIS; MUCOEPIDERMOID CARCINOMA; RADIATION-THERAPY; PHASE-II; ANDROGEN RECEPTOR; C-KIT; DIFFERENTIAL-DIAGNOSIS;

D O I：

10.1016/j.otc.2015.11.001

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Malignant parotid tumors are heterogeneous and diverse. Accurate diagnosis requires a pathologist familiar with the various histologic sub-types, immunohistochemistry stains, and common translocations. Clinical course varies according to tumor subtype, ranging from indolent, slow growing adenoid cystic carcinoma to rapidly progressive, often fatal, salivary ductal carcinoma. Histologic grade is important in prognosis and therapy. Surgery remains the mainstay of treatment when negative margins can be achieved. Radiation improves locoregional control of tumors with high-risk features. Chemotherapy for parotid tumors can be disappointing. Studies of new targeted therapies have not offered significant benefits.

引用

页码：343 / +

页数：39

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