Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation

被引：36
|
作者：
Chu, Pei-Yi [1 ]
Hsu, Dur-Zong [1 ]
Hsu, Pin-Yen [1 ]
Liu, Ming-Yie [1 ,2 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70428, Taiwan
[2] Natl Cheng Kung Univ, Sustainable Environm Res Ctr, Tainan 70428, Taiwan
来源：
INNATE IMMUNITY | 2010年 / 16卷 / 05期
关键词：
inflammation; lipopolysaccharide; nuclear factor-kappa B; pro-inflammatory mediators; sesamol; TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; SYNERGISTIC INTERACTIONS; OXIDATIVE STRESS; CECAL LIGATION; SEVERE SEPSIS; INTERLEUKIN-1; CYTOKINE; TNF; EXPRESSION;
D O I：
10.1177/1753425909351880
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We examined the effects of sesamol on the lipopolysaccharide (LPS)-induced inflammatory response. Sesamol inhibited serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and nitrite production in LPS-treated mice, and inhibited LPS-induced inducible nitric oxide synthase expression in mouse leukocytes. Sesamol also down-regulated TNF-alpha, IL-1 beta, and nitrite production as well as inducible nitric oxide synthase expression in LPS-treated RAW 264.7 cells. Further, sesamol inhibited LPS-induced nuclear factor (NF)-kappa B translocation and inhibitor (I) kappa B-alpha phosphorylation in RAW 264.7 cells. By inhibiting TNF-alpha, IL-1 beta, and nitrite levels, and interfering with the NFkB kappa B pathway, sesamol down-regulated the LPS-initiated inflammatory response.
引用
收藏
页码：333 / 339
页数：7
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