Effect of Carriers on Loading of Self Nanoemulsifying Drug Delivery System

The objective of this study is to investigate solid self-nanoemulsifying drug delivery system (S-SNEDDS), as potential delivery system for poorly water soluble drug [atorvastatin calcium (AC)]. Self-nanoemulsification regions were determined by pseudo-ternary phase diagrams. The nanoennulsion selected was loaded into solid carriers (Aerosil 200, Porous polystyrene beads and Accurel MP 1000) by adsorption technique. The prepared S-SNEDDS were characterized and evaluated. The optimized emulsion selected from phase diagram contains 15% CapmulMCM (oil), 14% Tween 20 (surfactant) and 28% propylene glycol (cosurfactant). FT-IR studies confirm there is no significant interaction. The loading efficiency and flow was higher with Aerosil 200, because of its large surface area. The results of characterization (SEM, DSC and XRD) show that the drug was present in dissolved form and no crystals were found. In vitro release studies depicit, all the prepared S-SNEDDS shows the release of more than 95% in 60 min, whereas the pure drug show only 36.73%. The in vivo studies shows that Cmax of drug loaded with Aerosil shows 6.93 folds more than pure AC. The AUC was found to be 386.2 mcg/ml, whereas for pure drug, it was 73.56 mcg/ml. AC S-SNEDDS successfully withstood the stability conditions throughout the study period.