Oxidative stress and vein graft failure: a focus on NADH oxidase, nitric oxide and eicosanoids

被引：31

作者：

Weaver, Helen ^{[1
]}

Shukla, Nilima ^{[1
]}

Ellinsworth, David ^{[1
]}

Jeremy, Jamie Y. ^{[1
]}

机构：

[1] Univ Bristol, Bristol Heart Inst, Bristol BS8 1TH, Avon, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 02期

关键词：

INHIBITS SUPEROXIDE FORMATION; SMOOTH-MUSCLE-CELLS; THROMBOXANE A(2) ANALOG; GP91(PHOX) EXPRESSION; ENDOTHELIAL-CELLS; CYTOKINES; ENDOTOXIN; SYNTHASE; ILOPROST;

D O I：

10.1016/j.coph.2012.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent interest has focused on superoxide and the upregulation of NADPH oxidase expression in the aetiology of vein graft failure. Implantation of saphenous vein grafts promotes upregulation of NADPH oxidase through a number of distinct interrelated mechanisms: (a)- endothelial denudation, (b) factors released by adherent platelets, monocytes and neutrophils, (c) hypoxia and (d) altered prostacyclin (PGI(2)) and enhanced isoprostane formation. These, in turn, impact on neointima (NI) formation (vascular smooth muscle cell [VSMC] replication and migration) and metalloproteinase (MMP) expression, key events in vein graft thickening. NADPH oxidase in the aetiology of vein graft failure will be discussed in this review with particular reference to nitric oxide and eicosanoids and related drugs that inhibit its activity and expression.

引用

页码：160 / 165

页数：6

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