The role of antioxidants in the chemistry of oxidative stress: A review

被引:1913
作者
Pisoschi, Aurelia Magdalena [1 ]
Pop, Aneta [1 ]
机构
[1] Univ Agron Sci & Vet Med Bucharest, Fac Vet Med, Bucharest 050097, Romania
关键词
Oxidative stress; Reactive oxygen/nitrogen species; Biomolecule impairment; Oxidative stress-induced pathology; Antioxidants; LOW-DENSITY-LIPOPROTEIN; TOXIC NITROGEN-OXIDES; LIPID-PEROXIDATION; FREE-RADICALS; REACTIVE OXYGEN; ALPHA-TOCOPHEROL; URIC-ACID; CARDIOVASCULAR-DISEASE; BETA-CAROTENE; NITRIC-OXIDE;
D O I
10.1016/j.ejmech.2015.04.040
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This Review Article is focused on the action of the reactive oxygenated species in inducing oxidative injury of the lipid membrane components, as well as on the ability of antioxidants (of different structures and sources, and following different mechanisms of action) in fighting against oxidative stress. Oxidative stress is defined as an excessive production of reactive oxygenated species that cannot be counteracted by the action of antioxidants, but also as a perturbation of cell redox balance. Reactive oxygenated/nitrogenated species are represented by superoxide anion radical, hydroxyl, alkoxyl and lipid peroxyl radicals, nitric oxide and peroxynitrite. Oxidative stress determines structure modifications and function modulation in nucleic acids, lipids and proteins. Oxidative degradation of lipids yields malondialdehyde and 4-hydroxynonenal, but also isoprostanes, from unsaturated fatty acids. Protein damage may occur with thiol oxidation, carbonylation, side-chain oxidation, fragmentation, unfolding and misfolding, resulting activity loss. 8-hydroxydeoxyguanosine is an index of DNA damage. The involvement of the reactive oxygenated/nitrogenated species in disease occurrence is described. The unbalance between the oxidant species and the antioxidant defense system may trigger specific factors responsible for oxidative damage in the cell: over-expression of oncogene genes, generation of mutagen compounds, promotion of atherogenic activity, senile plaque occurrence or inflammation. This leads to cancer, neurodegeneration, cardiovascular diseases, diabetes, kidney diseases. The concept of antioxidant is defined, along with a discussion of the existent classification criteria: enzymatic and non-enzymatic, preventative or repair-systems, endogenous and exogenous, primary and secondary, hydrosoluble and liposoluble, natural or synthetic. Primary antioxidants are mainly chain breakers, able to scavenge radical species by hydrogen donation. Secondary antioxidants are singlet oxygen quenchers, peroxide decomposers, metal chelators, oxidative enzyme inhibitors or UV radiation absorbers. The specific mechanism of action of the most important representatives of each antioxidant class (endogenous and exogenous) in preventing or inhibiting particular factors leading to oxidative injury in the cell, is then reviewed. Mutual influences, including synergistic effects are presented and discussed. Prooxidative influences likely to occur, as for instance in the presence of transition metal ions, are also reminded. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:55 / 74
页数:20
相关论文
共 303 条
[1]  
Acuña-Castroviejo D, 2003, ADV EXP MED BIOL, V527, P549
[2]   Oxidative damage, plasma antioxidant capacity, and glucemic control in elderly NIDDM patients [J].
Aguirre, F ;
Martin, I ;
Grinspon, D ;
Ruiz, M ;
Hager, A ;
De Paoli, T ;
Ihlo, J ;
Farach, HA ;
Poole, CP .
FREE RADICAL BIOLOGY AND MEDICINE, 1998, 24 (04) :580-585
[3]   Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters [J].
Agus, DB ;
Gambhir, SS ;
Pardridge, WM ;
Spielholz, C ;
Baselga, J ;
Vera, JC ;
Golde, DW .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (11) :2842-2848
[4]   A Facile Electrochemical Analysis to Determine Antioxidant Activity of Flavonoids against DPPH Radical [J].
Ahmed, Safeer ;
Tabassum, Sajida ;
Shakeel, Faria ;
Khan, Athar Yaseen .
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 2012, 159 (05) :F103-F109
[5]   S-(2-succinyl)cysteine:: A novel chemical modification of tissue proteins by a Krebs cycle intermediate [J].
Alderson, Nathan L. ;
Wang, Yuping ;
Blatnik, Matthew ;
Frizzell, Norma ;
Walla, Michael D. ;
Lyons, Timothy J. ;
Alt, Nadja ;
Carson, James A. ;
Nagai, Ryji ;
Thorpe, Suzanne R. ;
Baynes, John W. .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 450 (01) :1-8
[6]   Antioxidant supplementations for prevention of atrial fibrillation after cardiac surgery: an updated comprehensive systematic review and meta-analysis of 23 randomized controlled trials [J].
Ali-Hassan-Sayegh, Sadegh ;
Mirhosseini, Seyed Jalil ;
Rezaeisadrabadi, Mohammad ;
Dehghan, Hamid Reza ;
Sedaghat-Hamedani, Farbod ;
Kayvanpour, Elham ;
Popov, Aron-Frederik ;
Liakopoulos, Oliver J. .
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, 2014, 18 (05) :646-654
[7]   URIC-ACID PROVIDES AN ANTIOXIDANT DEFENSE IN HUMANS AGAINST OXIDANT-CAUSED AND RADICAL-CAUSED AGING AND CANCER - A HYPOTHESIS [J].
AMES, BN ;
CATHCART, R ;
SCHWIERS, E ;
HOCHSTEIN, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (11) :6858-6862
[8]   Longitudinal associations between body mass index and serum carotenoids: the CARDIA study [J].
Andersen, LF ;
Jacobs, DR ;
Gross, MD ;
Schreiner, PJ ;
Williams, OD ;
Lee, DH .
BRITISH JOURNAL OF NUTRITION, 2006, 95 (02) :358-365
[9]   N-acetylcysteine improves coronary and peripheral vascular function [J].
Andrews, NP ;
Prasad, A ;
Quyyumi, AA .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (01) :117-123
[10]  
[Anonymous], 2000, REPORT PANEL DIETARY, P35