Induction of remission following a single dose of rituximab alone in a patient with minimal change nephrotic syndrome

被引：9
|
作者：
Amemiya, Nobuyuki [1 ]
Takei, Takashi [1 ]
Kojima, Chiari [1 ]
Nokiba, Hirohiko [1 ]
Itabashi, Mitsuyo [1 ]
Nitta, Kosaku [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Med, Kidney Ctr, Shinjuku Ku, Tokyo 1628666, Japan
来源：
CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2011年 / 15卷 / 06期
关键词：
Frequently relapsing minimal change nephrotic syndrome; Rituximab; Monotherapy; THERAPY; RELAPSE;
D O I：
10.1007/s10157-011-0510-5
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Treatment with a single dose of rituximab alone induced remission in a patient with relapsed minimal change nephrotic syndrome (MCNS). A 27-year-old man was given corticosteroid (prednisolone; PSL) and cyclosporine (CyA) therapy combined with rituximab for his fifth relapse in 2008. Thereafter, complete remission was achieved and maintained despite eventual discontinuation of the PSL and CyA. In 2010, we treated his sixth relapse with a single dose of rituximab. Complete remission was obtained 32 days later. This is the first report of rituximab monotherapy in the treatment of MCNS.
引用
收藏
页码：933 / 936
页数：4
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