Modified enzyme immunoassay to detect hepatitis C virus antibodies in oral fluid

被引：29

作者：

McIntyre, PG ^{[1
]}

Laszlo, J ^{[1
]}

Appleyard, K ^{[1
]}

Ogden, GR ^{[1
]}

机构：

[1] DENT HOSP,DEPT DENT SURG & PERIODONTOL,DUNDEE,SCOTLAND

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1996年 / 15卷 / 11期

关键词：

D O I：

10.1007/BF01691223

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Samples of oral fluid collected from 18 patients seropositive for hepatitis C virus (HCV) and 49 seronegative patients were tested for the presence of HCV antibodies with two modified serum-screening kits. The following sensitivities and specificities were obtained: HCV 3.0 assay, 72% and 98%, respectively, and Monolisa anti-HCV assay, 100% and 100%, respectively. The modified Monolisa assay demonstrated a striking concordance between serum and saliva samples. The use of oral fluids offers a convenient and noninvasive method applicable to HCV epidemiological studies and screening of high-risk groups.

引用

页码：882 / 884

页数：3

共 7 条

[1] DRUG INJECTION AND HIV PREVALENCE IN INMATES OF GLENOCHIL PRISON [J].

GORE, SM ;

BIRD, AG ;

BURNS, SM ;

GOLDBERG, DJ ;

ROSS, AJ ;

MACGREGOR, J .

BRITISH MEDICAL JOURNAL, 1995, 310 (6975) :293-296

[2] COMPARISON OF SALIVA AND BLOOD FOR HUMAN-IMMUNODEFICIENCY-VIRUS PREVALENCE TESTING [J].

MAJOR, CJ ;

READ, SE ;

COATES, RA ;

FRANCIS, A ;

MCLAUGHLIN, BJ ;

MILLSON, M ;

SHEPHERD, F ;

FANNING, M ;

CALZAVARA, L ;

MACFADDEN, D ;

JOHNSON, JK ;

OSHAUGHNESSY, MV .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (04) :699-702

[3] SENSITIVE ASSAYS FOR VIRAL ANTIBODIES IN SALIVA - AN ALTERNATIVE TO TESTS ON SERUM [J].

PARRY, JV ;

PERRY, KR ;

MORTIMER, PP .

LANCET, 1987, 2 (8550) :72-75

[4]

PERRY KR, 1995, 10 ANTI HCV SCREENIN

[5] Hepatitis C virus in saliva of haemophiliac patients attending an oral surgery unit [J].

Roy, KM ;

Bagg, J ;

Follett, EA ;

Brewer, A ;

Lowe, GD .

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 1996, 34 (02) :162-165

[6]

SHERMAN KE, 1994, AM J GASTROENTEROL, V89, P2025

[7] CLINICAL-EVALUATION OF ORAL FLUID SAMPLES FOR DIAGNOSIS OF VIRAL-HEPATITIS [J].

THIEME, T ;

YOSHIHARA, P ;

PIACENTINI, S ;

BELLER, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (05) :1076-1079

← 1 →