Facile synthesis, antimicrobial, and anti-inflammatory activities of novel isoxazolyl imidazo[1,2-b]isoxazoles

被引：4
作者：
Krishna, Saini Rama [1 ]
Nagaraju, Dharavath [2 ]
Reddy, Malladi Srinivas [3 ]
Rajanarendar, Eligeti [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India
[2] Telangana Univ, Dept Chem, Nizamabad, India
[3] Vaageswari Coll Pharm, Dept Pharmaceut Chem, Karimnagar, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2022年 / 59卷 / 08期
关键词：
IN-VITRO; ANTICANCER ACTIVITY; POTENT; TEMOZOLOMIDE; DERIVATIVES; INHIBITORS; AFFINITY; COX-2;
D O I：
10.1002/jhet.4473
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper iodide promoted cyclization for the synthesis of isoxazolyl imidazo[1,2-b]isoxazoles 3 in a one-pot procedure has been investigated by interaction of 3-aminoisoxazole 1 with nitrostyrylisoxazoles 2 under aerial oxidation condition. The newly synthesized compounds 3a-l were screened for their in vitro antimicrobial and anti-inflammatory activities.
引用
收藏
页码：1341 / 1349
页数：9
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