The biological role of HGF-MET axis in tumor growth and development of metastasis

被引：85

作者：

Lesko, Ewa ^{[1
]}

Majka, Marcin ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Transplantat, Polish Amer Inst Pediat, Sch Med, Krakow, Poland

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷

关键词：

cancer; tumor; neoplasia; hepatocyte growth factor; HGF-MET; metastasis; review;

D O I：

10.2741/2760

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocyte growth factor (HGF) and its receptor MET play an important role in cancer growth and metastasis. Activation of MET elicit multiple cellular responses regulating cell survival, morphogenesis, adhesion, migration, breakdown of extracellular matrix (ECM) and angiogenesis. Numerous disorders related to deregulation of HGF-MET axis have been reported. Thus, new therapeutic agents targeting HGF-MET signaling have been sought. Here, we will present data describing the role of HGF-MET axis in growth and metastasis of tumor cells together with the recent approaches to block this axis.

引用

页码：1271 / 1280

页数：10

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