Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages

被引:34
作者
Arkwright, PD [1 ]
David, TJ [1 ]
机构
[1] Univ Manchester, Booth Hall Childrens Hosp, Acad Unit Child Hlth, Manchester M9 7AA, Lancs, England
关键词
age; atopic dermatitis; children; Mycobacterium vaccae; randomized controlled trial;
D O I
10.1111/j.1365-2133.2003.05557.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Exposure to environmental microorganisms is associated with variations in the prevalence and severity of atopic diseases. We have previously shown that administration of a Mycobacterium vaccae suspension significantly reduced the severity of atopic dermatitis (AD) in children aged 5-18 years. Objectives This study aimed to extend these observations to younger children. Methods Fifty-six children aged 2-6 years with moderate to severe AD were enrolled in a randomized, double-blind, placebo-controlled trial and given one intradermal injection of either killed M. vaccae suspension or buffer solution (placebo). Skin surface area affected and dermatitis severity score were assessed before and 1, 3 and 6 months after treatment. Results Although a 38-54% reduction in surface area affected by dermatitis was noted at all time points after M. vaccae administration (P = 0.005), this improvement was not significantly different from that observed in the placebo group. Meta-analysis of this and our previous cohort (97 children aged 2-18 years) showed that M. vaccae was associated with a significant improvement in clinical severity at all ages, whereas within the placebo group, younger but not older children showed a similar improvement. Conclusions Despite a reduction in clinical severity associated with M. vaccae at all ages, no benefit could be found after administering M. vaccae to children with AD aged 2-6 years when compared with placebo. M. vaccae may offer greater benefit in children over 5 years old, whose AD appears less likely to regress spontaneously.
引用
收藏
页码:1029 / 1034
页数:6
相关论文
共 16 条
[1]   Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease [J].
Arkwright, PD ;
David, TJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (03) :531-534
[2]   Atopic dermatitis is associated with a low-producer transforming growth factor β1 cytokine genotype [J].
Arkwright, PD ;
Chase, JM ;
Babbage, S ;
Pravica, V ;
David, TJ ;
Hutchinson, IV .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (02) :281-+
[4]   The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma [J].
Camporota, L ;
Corkhill, A ;
Long, H ;
Lordan, J ;
Stanciu, L ;
Tuckwell, N ;
Cross, A ;
Stanford, JL ;
Rook, GAW ;
Holgate, ST ;
Djukanovic, R .
EUROPEAN RESPIRATORY JOURNAL, 2003, 21 (02) :287-293
[5]   LOW SERUM ZINC IN CHILDREN WITH ATOPIC ECZEMA [J].
DAVID, TJ ;
WELLS, FE ;
SHARPE, TC ;
GIBBS, ACC .
BRITISH JOURNAL OF DERMATOLOGY, 1984, 111 (05) :597-601
[6]  
de Lafaille MAC, 2002, CURR OPIN IMMUNOL, V14, P771
[7]   Early childhood infection and atopic disorder [J].
Farooqi, IS ;
Hopkin, JM .
THORAX, 1998, 53 (11) :927-932
[8]   Probiotics in primary prevention of atopic disease:: a randomised placebo-controlled trial [J].
Kalliomäki, M ;
Salminen, S ;
Arvilommi, H ;
Kero, P ;
Koskinen, P ;
Isolauri, E .
LANCET, 2001, 357 (9262) :1076-1079
[9]  
Leung DYM, 2001, J AM ACAD DERMATOL, V45, pS13, DOI 10.1067/mjd.2001.117024
[10]  
Miller FJW, 1963, Tuberculosis in children