We propose a generalized radiation-field quantization formalism, where quantization does not have to be referenced to a set of power-orthogonal eigenmodes as conventionally required. This formalism can be used to directly quantize the true system eigenmodes, which can be non-power-orthogonal due to the open nature of the system or the gain/loss medium involved in the system. We apply this generalized field quantization to the laser linewidth problem, in particular, lasers with non-power-orthogonal oscillation modes, and derive the excess-noise factor in a fully quantum-mechanical framework. We also show that, despite the excess-noise factor for oscillating modes, the total spatially averaged decay rate for the laser atoms remains unchanged.