Parthenolide could become a promising and stable drug with anti-inflammatory effects

被引：51
作者：
Wang, Mengting [1 ,2 ]
Li, Qiyan [1 ,2 ,3 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Med, Kunming, Peoples R China
[2] Kunming Univ Sci & Technol, Affiliated Hosp, Kunming, Peoples R China
[3] First Peoples Hosp Yunnan Prov, Kunming, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 12期
关键词：
chemical structure; pharmacology; anti-inflammation; parthenolide; SESQUITERPENE LACTONE PARTHENOLIDE; NF-KAPPA-B; GENE-TRANSCRIPTION PROFILES; TANACETUM-PARTHENIUM; CYTOKINE PRODUCTION; TNF-ALPHA; IN-VITRO; INHIBITION; CELLS; ACTIVATION;
D O I：
10.1080/14786419.2014.981541
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The aim of this paper is to summarise the blocking effects of parthenolide on the cytokines and pathways that cause inflammation. Analyses of the chemical structure of parthenolide have tried to identify the active domains that play key roles in its anti-inflammatory activity. This review focuses on the anti-inflammatory actions of parthenolide in both in vitro and in vivo. These data will be helpful for future investigations into the effects of parthenolide on inflammation.
引用
收藏
页码：1092 / 1101
页数：10
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