Copper-Catalyzed Oxidative 1,2-Alkylarylation of Styrenes with Unactivated C(sp3)-H Alkanes and Electron-Rich Aromatics via C(sp3)-H/C(sp2)-H Functionalization

We have disclosed an alkenes dicarbofunctionalization method to introduce alkyl and electron-rich aryl across the C=C bond of styrenes under copper catalyst and oxidative conditions, leading to construct C(sp(3))-C(sp(2))/C(sp(3))-C(sp(3)) bonds via dual C-H functionalization. This method realizes the synthesis of 1,1-diarylalkanes, which are very important skeleton in natural products and drug molecules, through the grafting of electron-rich aromatics, including indoles, pyrroles, trisubstituted aromatic.