Direct C-H Difluoroalkylation of Heteroarenes with Difluoroalkyl Carboxylic Acids

被引：14

作者：

Guo, Chunfang ^{[1
,2
]}

Han, Xuliang ^{[1
]}

Li, Xiangye ^{[1
]}

Diao, Zhengzhen ^{[1
]}

Li, Xinjin ^{[1
,3
]}

Dong, Yunhui ^{[1
]}

机构：

[1] Shandong Univ Technol, Sch Chem & Chem Engn, 266 West Xincun Rd, Zibo 255000, Peoples R China

[2] Shandong Vocat Coll Light Ind, Zhoucun Mishan Rd, Zibo 255300, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 01期

关键词：

difluoroalkylation; silver-catalyzed; C-H functionalization; heteroarenes; difluoroalkyl carboxylic acid; OXIDATIVE ACTIVATION; SYNTHETIC METHODS; TRIFLUOROMETHYLATION; REAGENT; 1,1-DIFLUOROETHYLATION; DIFLUOROMETHYLATION; ARENES; INHIBITORS; FLUORINE; POTENT;

D O I：

10.1002/ajoc.202100663

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the difluoroalkylation of heteroaromatic compounds has been developed by employing readily available difluoroalkyl carboxylic acids. This silver-catalyzed reaction proceeds under mild conditions and affords a broad range of difluoroalkylated heteroarenes in moderate to good yields, including pyridines, pyrimidines, pyrazines, quinolines, quinoxalines as well as bioactive compounds.

引用

页数：5

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