Distinct cytokine profile in SIDS brain -: A common denominator in a multifactorial syndrome?

被引：29

作者：

Kadhim, H

Kahn, A

Sébire, G

机构：

[1] Catholic Univ Louvain, Clin Univ St Luc, NEPE, Lab Neurol Dev, B-1200 Brussels, Belgium

[2] Free Univ Brussels, CHU Brugmann, HUDERF, Serv Anatomopathol,Unite Neuropathol, B-1050 Brussels, Belgium

[3] Free Univ Brussels, Hop Univ Enfants Reine Fabiola HUDERF, Serv Pediat, B-1050 Brussels, Belgium

[4] Univ Sherbrooke, Serv Neurol Pediat, CHU Fleurimont, Sherbrooke, PQ J1K 2R1, Canada

来源：

NEUROLOGY | 2003年 / 61卷 / 09期

关键词：

D O I：

10.1212/01.WNL.0000092014.14997.47

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1beta immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.

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页码：1256 / 1259

页数：4

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