Hypermagnesemia does not increase brain intracellular magnesium in newborn swine

被引：23
作者：
Gee, JB
Corbett, RJT
Perlman, JM
Laptook, AR
机构：
[1] Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75390 USA
[2] Texas Womens Hosp, Houston, TX USA
[3] Univ Texas, SW Med Ctr, Dept Radiol, Mary Nell & Ralph B Rogers Magnet Resonance Ctr, Dallas, TX 75390 USA
来源：
PEDIATRIC NEUROLOGY | 2001年 / 25卷 / 04期
关键词：
D O I：
10.1016/S0887-8994(01)00317-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Phosphorus-31 magnetic resonance spectroscopy was used in 2-day (n = 4) and 40-day (n = 4) miniswine to determine whether plasma hypermagnesemia alters brain intracellular magnesium concentration and if the plasma-brain intracellular magnesium relationship changes with age. At control, brain intracellular magnesium concentration was similar in the 2-day (0.24 +/- 0.04 mM) and 40-day groups (0.21 +/- 0.01 mM). Intravenous infusions of magnesium sulfate (MgSO4, 60 minute) raised plasma magnesium concentration to 4-6 mM in both groups. During and for 3 hours after MgSO4 infusions, there were no changes in brain intracellular magnesium concentration in either group and no correlation between plasma and brain intracellular magnesium (r = 0.11 and 0.08 for 2- and 40-day groups, respectively). Brain intracellular magnesium concentration appears to be tightly regulated. (C) 2001 by Elsevier Science Inc. All rights reserved.
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页码：304 / 308
页数：5
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