Hydrogel microfabrication technology toward three dimensional tissue engineering

被引：91

作者：

Yanagawa, Fumiki ^{[1
]}

Sugiura, Shinji ^{[1
]}

Kanamori, Toshiyuki ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Drug Assay Device Res Grp, Biotechnol Res Inst Drug Discovery, Cent 5th,1-1-1 Higashi, Tsukuba, Ibaraki 3058565, Japan

来源：

REGENERATIVE THERAPY | 2016年 / 3卷

关键词：

Hydrogels; Microfabrication; Tissue engineering; Microfluidics; Perfusion; STOP-FLOW LITHOGRAPHY; IN-VITRO; CELL ENCAPSULATION; 2-PHOTON POLYMERIZATION; MICROVASCULAR NETWORKS; GELATIN HYDROGELS; BIODEGRADABLE HYDROGELS; EXTRACELLULAR-MATRIX; STEM-CELLS; FABRICATION;

D O I：

10.1016/j.reth.2016.02.007

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The development of biologically relevant three-dimensional (3D) tissue constructs is essential for the alternative methods of organ transplantation in regenerative medicine, as well as the development of improved drug discovery assays. Recent technological advances in hydrogel microfabrication, such as micromolding, 3D bioprinting, photolithography, and stereolithography, have led to the production of 3D tissue constructs that exhibit biological functions with precise 3D microstructures. Furthermore, microfluidics technology has enabled the development of the perfusion culture of 3D tissue constructs with vascular networks. In this review, we present these hydrogel microfabrication technologies for the in vitro reconstruction and cultivation of 3D tissues. Additionally, we discuss current challenges and future perspectives of 3D tissue engineering. (c) 2016, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

引用

页码：45 / 57

页数：13

共 146 条

[31] Hydrogel microfluidics for the patterning of pluripotent stem cells [J].