Incorporating Biomarker Stratification into STAMPEDE: an Adaptive Multi-arm, Multi-stage Trial Platform

被引：16

作者：

Gilson, C. ^{[1
]}

Chowdhury, S. ^{[2
]}

Parmar, M. K. B. ^{[1
]}

Sydes, M. R. ^{[1
]}

机构：

[1] UCL, MRC Clin Trials Unit, London, England

[2] Guys & St Thomas NHS Fdn Trust, London, England

来源：

CLINICAL ONCOLOGY | 2017年 / 29卷 / 12期

关键词：

Biomarkers; clinical trial design; platform trials; precision medicine; prostate cancer; PROSTATE-CANCER; HORMONE AGONISTS; TRANSDERMAL ESTROGEN; MAINTENANCE THERAPY; BREAST-CANCER; OPEN-LABEL; MUTATIONS; REPAIR; OLAPARIB; LETHAL;

D O I：

10.1016/j.clon.2017.10.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The treatment and outcomes for advanced prostate cancer have experienced significant progress over recent years. Importantly, the additional benefits of 'up front' chemotherapy (docetaxel) and abiraterone, over and above conventional androgen deprivation, have been separately demonstrated in the multi-arm, multi-stage (MAMS) STAMPEDE protocol, which continues recruitment to other questions. Alongside this, insights into the underlying molecular biology and, inevitably, the molecular heterogeneity of prostate cancer are opening the door to new therapeutic approaches. Incorporating this understanding and testing these hypotheses within STAMPEDE brings new challenges to the MAMS approach, but has the potential to further improve the outlook for this disease. (c) 2017 The Royal College of Radiologists. Published by Elsevier Ltd.

引用

页码：778 / 786

页数：9

共 54 条

[1] The Molecular Taxonomy of Primary Prostate Cancer [J].

Abeshouse, Adam ;

Ahn, Jaeil ;

Akbani, Rehan ;

Ally, Adrian ;

Amin, Samirkumar ;

Andry, Christopher D. ;

Annala, Matti ;

Aprikian, Armen ;

Armenia, Joshua ;

Arora, Arshi ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Barbieri, Christopher E. ;

Bauer, Thomas ;

Benz, Christopher C. ;

Bergeron, Alain ;

Beroukhim, Rameen ;

Berrios, Mario ;

Bivol, Adrian ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

dos Reis, Rodolfo Borges ;

Boutros, Paul C. ;

Bowen, Jay ;

Bowlby, Reanne ;

Boyd, Jeffrey ;

Bradley, Robert K. ;

Breggia, Anne ;

Brimo, Fadi ;

Bristow, Christopher A. ;

Brooks, Denise ;

Broom, Bradley M. ;

Bryce, Alan H. ;

Bubley, Glenn ;

Burks, Eric ;

Butterfield, Yaron S. N. ;

Button, Michael ;

Canes, David ;

Carlotti, Carlos G. ;

Carlsen, Rebecca ;

Carmel, Michel ;

Carroll, Peter R. ;

Carter, Scott L. ;

Cartun, Richard ;

Carver, Brett S. ;

Chan, June M. ;

Chang, Matthew T. ;

Chen, Yu .

CELL, 2015, 163 (04) :1011-1025

[2] Prioritizing targets for precision cancer medicine [J].

Andre, F. ;

Mardis, E. ;

Salm, M. ;

Soria, J. -C. ;

Siu, L. L. ;

Swanton, C. .

ANNALS OF ONCOLOGY, 2014, 25 (12) :2295-2303

[3] Punctuated Evolution of Prostate Cancer Genomes [J].

Baca, Sylvan C. ;

Prandi, Davide ;

Lawrence, Michael S. ;

Mosquera, Juan Miguel ;

Romanel, Alessandro ;

Drier, Yotam ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Ghandi, Mahmoud ;

Van Allen, Eliezer ;

Kryukov, Gregory V. ;

Sboner, Andrea ;

Theurillat, Jean-Philippe ;

Soong, T. David ;

Nickerson, Elizabeth ;

Auclair, Daniel ;

Tewari, Ashutosh ;

Beltran, Himisha ;

Onofrio, Robert C. ;

Boysen, Gunther ;

Guiducci, Candace ;

Barbieri, Christopher E. ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Ramos, Alex H. ;

Winckler, Wendy ;

Cipicchio, Michelle ;

Ardlie, Kristin ;

Kantoff, Philip W. ;

Berger, Michael F. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Elemento, Olivier ;

Getz, Gad ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Garraway, Levi A. .

CELL, 2013, 153 (03) :666-677

[4] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer [J].

Barbieri, Christopher E. ;

Baca, Sylvan C. ;

Lawrence, Michael S. ;

Demichelis, Francesca ;

Blattner, Mirjam ;

Theurillat, Jean-Philippe ;

White, Thomas A. ;

Stojanov, Petar ;

Van Allen, Eliezer ;

Stransky, Nicolas ;

Nickerson, Elizabeth ;

Chae, Sung-Suk ;

Boysen, Gunther ;

Auclair, Daniel ;

Onofrio, Robert C. ;

Park, Kyung ;

Kitabayashi, Naoki ;

MacDonald, Theresa Y. ;

Sheikh, Karen ;

Vuong, Terry ;

Guiducci, Candace ;

Cibulskis, Kristian ;

Sivachenko, Andrey ;

Carter, Scott L. ;

Saksena, Gordon ;

Voet, Douglas ;

Hussain, Wasay M. ;

Ramos, Alex H. ;

Winckler, Wendy ;

Redman, Michelle C. ;

Ardlie, Kristin ;

Tewari, Ashutosh K. ;

Mosquera, Juan Miguel ;

Rupp, Niels ;

Wild, Peter J. ;

Moch, Holger ;

Morrissey, Colm ;

Nelson, Peter S. ;

Kantoff, Philip W. ;

Gabriel, Stacey B. ;

Golub, Todd R. ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad ;

Rubin, Mark A. ;

Garraway, Levi A. .

NATURE GENETICS, 2012, 44 (06) :685-U107

[5] Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity [J].

Beltran, Himisha ;

Yelensky, Roman ;

Frampton, Garrett M. ;

Park, Kyung ;

Downing, Sean R. ;

MacDonald, Theresa Y. ;

Jarosz, Mirna ;

Lipson, Doron ;

Tagawa, Scott T. ;

Nanus, David M. ;

Stephens, Philip J. ;

Mosquera, Juan Miguel ;

Cronin, Maureen T. ;

Rubin, Mark A. .

EUROPEAN UROLOGY, 2013, 63 (05) :920-926

[6] Ten Years on the Juggernaut Keeps on Rolling: Comments on the STAMPEDE Trial from the Front Line [J].

Birtle, A. ;

Barber, J. .

CLINICAL ONCOLOGY, 2016, 28 (09) :547-549

[7] Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination [J].

Buisson, Remi ;

Dion-Cote, Anne-Marie ;

Coulombe, Yan ;

Launay, Helene ;

Cai, Hong ;

Stasiak, Alicja Z. ;

Stasiak, Andrzej ;

Xia, Bing ;

Masson, Jean-Yves .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (10) :1247-+

[8] Use of transdermal estrogen in the management of advanced prostate cancer [J].

Cafferty, Fay H. ;

Langley, Ruth E. ;

Abel, Paul D. .

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2013, 31 (02) :279-279

[9]

Cancer Research UK, CANC RES UK BIOM ROA

[10]

Castro E, 2017, PROREPAIR B PROSPECT

← 1 2 3 4 5 6 →