DNA-binding, oxidative DNA cleavage, and coordination mode of later 3d transition metal complexes of a Schiff base derived from isatin as antimicrobial agents

被引：45

作者：

Raman, N. ^{[1
]}

Pothiraj, K. ^{[1
]}

Baskaran, T. ^{[1
]}

机构：

[1] VHNSN Coll, Dept Chem Res, Virudunagar 626001, India

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2011年 / 64卷 / 22期

关键词：

Schiff base; Metal complexes; DNA cleavage; Metal-DNA interaction; Antimicrobial studies; CALF THYMUS DNA; COPPER(II) COMPLEXES; ELECTRONIC-PROPERTIES; CRYSTAL-STRUCTURE; MANNICH-BASES; ANTIBACTERIAL; LIGAND; STEREOCHEMISTRY; TRIS(PHENANTHROLINE)RUTHENIUM(II); MANGANESE(II);

D O I：

10.1080/00958972.2011.634005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A Schiff base, obtained by the condensation of isatin monohydrazone with 2,3,5-trichlorobenzaldehyde, and its Co(II), Ni(II), Cu(II), and Zn(II) complexes have been synthesized and characterized. The interaction of these complexes with DNA is investigated using viscosity, absorption titration, and electrochemical techniques. The results indicate that the complexes bind to Calf thymus DNA through intercalation. Oxidative cleavage activities of the complexes are studied using supercoiled pBR322 DNA by gel electrophoresis. Antimicrobial study reveals that copper and zinc complexes are better antimicrobial agents than the Schiff base and its other complexes.

引用

页码：3900 / 3917

页数：18

共 64 条

[1]

[Anonymous], SYNTHESIS TECHNIQUES

[2]

[Anonymous], 1996, REV EXPANDED

[3] Synthesis of new chiral heterocyclic Schiff base modulated Cu(II)/Zn(II) complexes: Their comparative binding studies with CT-DNA, mononucleotides and cleavage activity [J].