A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications

被引：842

作者：

Wright, George W. ^{[1
]}

Huang, Wei ^{[2
]}

Phelan, James D. ^{[2
]}

Coulibaly, Zana A. ^{[2
]}

Roulland, Sandrine ^{[2
]}

Young, Ryan M. ^{[2
]}

Wang, James Q. ^{[2
]}

Schmitz, Roland ^{[2
]}

Morin, Ryan D. ^{[3
]}

Tang, Jeffrey ^{[3
]}

Jiang, Aixiang ^{[3
]}

Bagaev, Aleksander ^{[4
]}

Plotnikova, Olga ^{[4
]}

Kotlov, Nikita ^{[4
]}

Johnson, Calvin A. ^{[5
]}

Wilson, Wyndham H. ^{[2
]}

Scott, David W. ^{[6
]}

Staudt, Louis M. ^{[2
]}

机构：

[1] NCI, Biometr Res Branch, Div Canc Diag & Treatment, NIH, Bethesda, MD 20892 USA

[2] NCI, Lymphoid Malignancies Branch, NIH, Bethesda, MD 20892 USA

[3] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

[4] BostonGene, Waltham, MA 02453 USA

[5] NIH, Off Intramural Res, Ctr Informat Technol, Bldg 10, Bethesda, MD 20892 USA

[6] British Columbia Canc, Vancouver, BC V5Z 4E6, Canada

来源：

CANCER CELL | 2020年 / 37卷 / 04期

关键词：

MARGINAL ZONE LYMPHOMA; I-KAPPA-B; GERMINAL CENTER; SOMATIC MUTATIONS; RECURRENT MUTATIONS; ANALYSIS REVEALS; PRIMARY BREAST; KINASE; EXOME; EXPRESSION;

D O I：

10.1016/j.ccell.2020.03.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of precision medicine approaches for diffuse large B cell lymphoma (DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity. Recent multiplatform genomic studies revealed the existence of genetic subtypes of DLBCL using clustering methodologies. Here, we describe an algorithm that determines the probability that a patient's lymphoma belongs to one of seven genetic subtypes based on its genetic features. This classification reveals genetic similarities between these DLBCL subtypes and various indolent and extranodal lymphoma types, suggesting a shared pathogenesis. These genetic subtypes also have distinct gene expression profiles, immune microenvironments, and outcomes following immunochemotherapy. Functional analysis of genetic subtype models highlights distinct vulnerabilities to targeted therapy, supporting the use of this classification in precision medicine trials.

引用

页码：551 / +

页数：32

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