Molecular Cytogenetic Analysis of a Gliosarcoma with Osseous Metaplasia

被引：3

作者：

Dahlback, H. S. S. ^{[1
,3
,4
]}

Gorunova, L. ^{[1
,3
]}

Micci, F. ^{[1
,3
]}

Scheie, D. ^{[5
]}

Brandal, P. ^{[1
,2
]}

Meling, T. R. ^{[6
]}

Heim, S. ^{[1
,3
,4
]}

机构：

[1] Norwegian Radium Hosp, Oslo Univ Hosp, Inst Med Informat, Sect Canc Cytogenet, NO-0310 Oslo, Norway

[2] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Oncol, Div Canc & Surg, NO-0310 Oslo, Norway

[3] Univ Oslo, Fac Med, Ctr Canc Biomed, Oslo, Norway

[4] Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway

[5] Univ Oslo, Rikshosp, Dept Pathol, N-0027 Oslo, Norway

[6] Univ Oslo, Rikshosp, Dept Neurosurg, N-0027 Oslo, Norway

来源：

CYTOGENETIC AND GENOME RESEARCH | 2011年 / 134卷 / 02期

关键词：

Array CGH; FISH; Gliosarcoma; Karyotyping; t(3; 21); GLIOBLASTOMA-MULTIFORME; PATHOLOGICAL FEATURES; MIXED GLIOBLASTOMA; HUMAN GLIOMAS; ARRAY-CGH; GENE; ABNORMALITIES; CHROMOSOME; GENOME; CELLS;

D O I：

10.1159/000326804

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7,-10,-13, and -22), the tumour cells also harboured a hitherto unknown t(3;21)(q13 similar to 21;q21 similar to 22). Copyright (C) 2011 S. Karger AG, Basel

引用

页码：88 / 95

页数：8

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