Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

被引：109

作者：

Hensley, Matthew K. ^{[1
]}

Bain, William G. ^{[1
,2
]}

Jacobs, Jana ^{[3
]}

Nambulli, Sham ^{[4
,5
]}

Parikh, Urvi ^{[3
]}

Cillo, Anthony ^{[6
,7
]}

Staines, Brittany ^{[3
]}

Heaps, Amy ^{[3
]}

Sobolewski, Michele D. ^{[3
]}

Rennick, Linda J. ^{[4
,5
]}

Macatangay, Bernard J. C. ^{[3
]}

Klamar-Blain, Cynthia ^{[3
]}

Kitsios, Georgios D. ^{[1
]}

Methe, Barbara ^{[1
]}

Somasundaram, Ashwin ^{[6
,8
]}

Bruno, Tullia C. ^{[6
]}

Cardello, Carly ^{[6
]}

Shan, Feng ^{[6
]}

Workman, Creg ^{[6
]}

Ray, Prabir ^{[1
,6
]}

Ray, Anuradha ^{[1
,6
]}

Lee, Janet ^{[1
,9
]}

Sethi, Rahil ^{[10
]}

Schwarzmann, William E. ^{[10
]}

Ladinsky, Mark S. ^{[11
]}

Bjorkman, Pamela J. ^{[11
]}

Vignali, Dario A. ^{[6
]}

Duprex, W. Paul ^{[4
,5
]}

Agha, Mounzer E. ^{[8
]}

Mellors, John W. ^{[3
]}

McCormick, Kevin D. ^{[3
]}

Morris, Alison ^{[1
]}

Haidar, Ghady ^{[3
]}

机构：

[1] Univ Pittsburgh, Dept Med, Sch Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

[2] Vet Affairs Pittsburgh Healthcare Syst, Pittsburgh, PA USA

[3] Univ Pittsburgh, Dept Med, Div Infect Dis, Sch Med, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Ctr Vaccine Res, Sch Med, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Dept Microbiol & Mol Genet, Sch Med, Pittsburgh, PA 15213 USA

[6] Univ Pittsburgh, Dept Immunol, Sch Med, Pittsburgh, PA 15213 USA

[7] Univ Pittsburgh, Tumor Microenvironm Ctr, Hillman Canc Ctr, Med Ctr, Pittsburgh, PA 15213 USA

[8] Univ Pittsburgh, Dept Internal Med, Med Ctr, Div Hematol,Oncol, Pittsburgh, PA 15213 USA

[9] Univ Pittsburgh, Acute Lung Injury Ctr Excellence, Pittsburgh, PA 15213 USA

[10] Univ Pittsburgh, Dept Biomed Informat, Sch Med, Pittsburgh, PA 15213 USA

[11] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷 / 03期

基金：

美国国家卫生研究院;

关键词：

COVID-19; SARS-CoV-2 immune responses; SARS-CoV-2; RNAemia; SARS-CoV-2 intrahost variation; infectivity; severe acute respiratory syndrome coronavirus 2; MATURATION ANTIGEN;

D O I：

10.1093/cid/ciab072

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 x 10(10) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.

引用

页码：E815 / E821

页数：7

共 19 条

[1] T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma [J].

Ali, Syed Abbas ;

Shi, Victoria ;

Maric, Irina ;

Wang, Michael ;

Stroncek, David F. ;

Rose, Jeremy J. ;

Brudno, Jennifer N. ;

Stetler-Stevenson, Maryalice ;

Feldman, Steven A. ;

Hansen, Brenna G. ;

Fellowes, Vicki S. ;

Hakim, Frances T. ;

Gress, Ronald E. ;

Kochenderfer, James N. .

BLOOD, 2016, 128 (13) :1688-1700

[2] B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma [J].

Carpenter, Robert O. ;

Evbuomwan, Moses O. ;

Pittaluga, Stefania ;

Rose, Jeremy J. ;

Raffeld, Mark ;

Yang, Shicheng ;

Gress, Ronald E. ;

Hakim, Frances T. ;

Kochenderfer, James N. .

CLINICAL CANCER RESEARCH, 2013, 19 (08) :2048-2060

[3] Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host [J].

Choi, Bina ;

Choudhary, Manish C. ;

Regan, James ;

Sparks, Jeffrey A. ;

Padera, Robert F. ;

Qiu, Xueting ;

Solomon, Isaac H. ;

Kuo, Hsiao-Hsuan ;

Boucau, Julie ;

Bowman, Kathryn ;

Das Adhikari, U. ;

Winkler, Marisa L. ;

Mueller, Alisa A. ;

Hsu, Tiffany Y. -T. ;

Desjardins, Michael ;

Baden, Lindsey R. ;

Chan, Brian T. ;

Walker, Bruce D. ;

Lichterfeld, Mathias ;

Brigl, Manfred ;

Kwon, Douglas S. ;

Kanjilal, Sanjat ;

Richardson, Eugene T. ;

Jonsson, A. Helena ;

Alter, Galit ;

Barczak, Amy K. ;

Hanage, William P. ;

Yu, Xu G. ;

Gaiha, Gaurav D. ;

Seaman, Michael S. ;

Cernadas, Manuela ;

Li, Jonathan Z. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) :2291-2293

[4] Anti-BCMA CAR T-cell therapy in multiple myeloma: can we do better? [J].

D'Agostino, Mattia ;

Raje, Noopur .

LEUKEMIA, 2020, 34 (01) :21-34

[5]

Garry R F., Mutations arising in SARS-CoV-2 spike on sustained human-to-human transmission and human-to-animal passage

[6] Humoral Immune Response to SARS-CoV-2 in Iceland [J].

Gudbjartsson, Daniel F. ;

Norddahl, Gudmundur L. ;

Melsted, Pall ;

Gunnarsdottir, Kristbjorg ;

Holm, Hilma ;

Eythorsson, Elias ;

Arnthorsson, Asgeir O. ;

Helgason, Dadi ;

Bjarnadottir, Kristbjorg ;

Ingvarsson, Ragnar F. ;

Thorsteinsdottir, Brynja ;

Kristjansdottir, Steinunn ;

Birgisdottir, Kolbrun ;

Kristinsdottir, Anna M. ;

Sigurdsson, Martin I. ;

Arnadottir, Gudny A. ;

Ivarsdottir, Erna V. ;

Andresdottir, Margret ;

Jonsson, Frosti ;

Agustsdottir, Arna B. ;

Berglund, Jonas ;

Eiriksdottir, Berglind ;

Fridriksdottir, Run ;

Gardarsdottir, Elisabet E. ;

Gottfredsson, Magnus ;

Gretarsdottir, Olafia S. ;

Gudmundsdottir, Steinunn ;

Gudmundsson, Kjartan R. ;

Gunnarsdottir, Thora R. ;

Gylfason, Arnaldur ;

Helgason, Agnar ;

Jensson, Brynjar O. ;

Jonasdottir, Aslaug ;

Jonsson, Hakon ;

Kristjansson, Thordur ;

Kristinsson, Karl G. ;

Magnusdottir, Droplaug N. ;

Magnusson, Olafur T. ;

Olafsdottir, Lovisa B. ;

Rognvaldsson, Solvi ;

le Roux, Louise ;

Sigmundsdottir, Gudrun ;

Sigurdsson, Asgeir ;

Sveinbjornsson, Gardar ;

Sveinsdottir, Kristin E. ;

Sveinsdottir, Maney ;

Thorarensen, Emil A. ;

Thorbjornsson, Bjarni ;

Thordardottir, Marianna ;

Saemundsdottir, Jona .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (18) :1724-1734

[7] Infections after anti-CD19 chimeric antigen receptor T-cell therapy for hematologic malignancies: timeline, prevention, and uncertainties [J].

Haidar, Ghady ;

Garner, Will ;

Hill, Joshua A. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2020, 33 (06) :449-457

[8]

Jacobs JL, 2020, CLIN INFECT DIS, DOI [10.1093/cid/ciaa1316, DOI 10.1093/CID/CIAA1316]

[9] COVID-19 outcomes in patients with hematologic disease [J].

Malard, Florent ;

Genthon, Alexis ;

Brissot, Eolia ;

van de Wyngaert, Zoe ;

Marjanovic, Zora ;

Ikhlef, Souhila ;

Banet, Anne ;

Lapusan, Simona ;

Sestilli, Simona ;

Corre, Elise ;

Paviglianiti, Annalisa ;

Adaeva, Rosa ;

M'Hammedi-Bouzina, Fella ;

Labopin, Myriam ;

Legrand, Ollivier ;

Dulery, Remy ;

Mohty, Mohamad .

BONE MARROW TRANSPLANTATION, 2020, 55 (11) :2180-2184

[10] Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma [J].

Raje, Noopur ;

Berdeja, Jesus ;

Lin, Yi ;

Siegel, David ;

Jagannath, Sundar ;

Madduri, Deepu ;

Liedtke, Michaela ;

Rosenblatt, Jacalyn ;

Maus, Marcela V. ;

Turka, Ashley ;

Lam, Lyh-Ping ;

Morgan, Richard A. ;

Friedman, Kevin ;

Massaro, Monica ;

Wang, Julie ;

Russotti, Greg ;

Yang, Zhihong ;

Campbell, Timothy ;

Hege, Kristen ;

Petrocca, Fabio ;

Quigley, M. Travis ;

Munshi, Nikhil ;

Kochenderfer, James N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (18) :1726-1737

← 1 2 →