The application of platelet-rich plasma for skin graft enrichment: A meta-analysis

被引：12

作者：

Chen, Jianguo ^{[1
]}

Wan, Yingying ^{[2
]}

Lin, Yan ^{[1
]}

Jiang, Haiyue ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Plast Surg Hosp, Dept Plast & Reconstruct Surg, 33 Badachu Rd, Beijing, Peoples R China

[2] China Acad Chinese Med Sci, Xi Yuan Hosp, Dept Internal Med, Beijing, Peoples R China

来源：

INTERNATIONAL WOUND JOURNAL | 2020年 / 17卷 / 06期

关键词：

adjuvant; meta-analysis; platelet-rich plasma; skin graft; skin graft take; STRATEGIES; EFFICACY; GEL;

D O I：

10.1111/iwj.13445

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Existing evidence demonstrated that the role of platelet-rich plasma (PRP) in skin graft enrichment is uncertain. The aim of this study was to evaluate the efficacy and safety of PRP for skin graft. PubMed, EMBASE, Web of Science, and Cochrane Library databases were searched for randomised controlled trials that compared outcomes of skin graft treated with PRP versus those treated with blank controls. The outcomes mainly included the rate of skin graft take, number of skin graft loss and haematoma formation, and complications. There were 11 studies involving a total of 910 cases of skin grafts. Compared with the control group, PRP group had a significantly higher rate of skin graft take (mean difference = 5.47%; 95% confidence interval [CI], 2.80%-8.14%;P < .0001), fewer number of skin graft loss (risk ratio [RR] = 0.26; 95% CI, 0.13-0.55;P= .0004) and fewer cases of haematoma formation (RR = 0.24; 95% CI, 0.11-0.54;P= .0006). There was no significant difference in the incidence of complications between two groups. This meta-analysis summarises current evidence and indicates that PRP is a safe and effective adjuvant for skin graft enrichment.

引用

页码：1650 / 1658

页数：9