Ischemic and hemorrhagic disturbances in cerebral circulation alter contractile responses of the rat middle cerebral artery

被引：9
作者：
Fadyukova, OE
Storozhevykh, TP
Pinelis, VG
Koshelev, VB
机构：
[1] Moscow MV Lomonosov State Univ, Fac Med, Moscow 117192, Russia
[2] Russian Acad Med Sci, Sci Ctr Childrens Hlth, Moscow 117296, Russia
来源：
BRAIN RESEARCH | 2004年 / 995卷 / 01期
关键词：
middle cerebral artery; serotonin; endothelin-1; cerebral ischemia; cerebral hemorrhage;
D O I：
10.1016/j.brainres.2003.09.062
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsiveness to endothelin-1 (ET-1), but reduced responsiveness to serotonin. These findings suggest that cerebral circulation disorders alter cerebrovascular function possibly leading to secondary disturbances in brain circulation. (C) 2003 Elsevier B.V. All rights reserved.
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收藏
页码：145 / 149
页数：5
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