Synthesis of L-[β-11C]amino acids using immobilized enzymes

被引：11

作者：

Ikemoto, M

Sasaki, M

Haradahira, T

Yada, T

Omura, H

Furuya, Y

Watanabe, Y

Suzuki, K ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Div Adv Technol Med Imaging, Chiba 263, Japan

[2] Ikeda Food Res Corp, Fukuyama, Hiroshima 721, Japan

[3] Sumitomo Heavy Ind Ltd, Shinagawa Ku, Tokyo 141, Japan

[4] Osaka Biosci Inst, Dept Neurosci, Suita, Osaka 565, Japan

[5] Japan Sci & Technol Corp, Subfemtomole Biorecognit Project, Suita, Osaka 565, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 1999年 / 50卷 / 04期

关键词：

carbon-11; L-[beta-C-11]-5-HTP; L-[beta-C-11]DOPA; enzymatic synthesis; PET;

D O I：

10.1016/S0969-8043(98)00143-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

L-[beta-C-11]-3,4-dihydroxyphenylalanine (L-[beta-C-11]DOPA) and L-[beta-C-11]-5-hydroxytryptophan(L-[beta-C-11]-5-HTP) were synthesized in one step with immobilized thermostable enzymes (alanine racemase, D-amino acid oxidase, and beta-tyrosinase or tryptophanase) on an aminopropyl-CPG carrier in a single column and by passing D,L-[3-C-11]alanine through the column with coenzymes and other substrates. L-[beta-C-11]DOPA and L-[beta-C-11]-5-HTP could be obtained at yields of 53% and 60%, respectively, by optimizing the amounts and the ratios of the enzymes used, the reaction temperature, the pH, and the flow rate. Moreover, the same immobilized enzyme column could be used repeatedly. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：715 / 721

页数：7

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