Azaphenanthrene Alkaloids with Antitumoral Activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae)

被引：13

作者：

Suassuna Carneiro Lucio, Ana Silvia ^{[1
]}

Guedes da Silva Almeida, Jackson Roberto ^{[2
]}

Barbosa-Filho, Jose Maria ^{[1
]}

Lima Rodrigues Pita, Joao Carlos ^{[1
]}

Sobral Castello Branco, Marianna Vieira ^{[1
]}

Formiga Melo Diniz, Margareth de Fatima ^{[1
]}

Agra, Maria de Fatima ^{[1
]}

da-Cunha, Emidio V. L. ^{[1
,3
]}

da Silva, Marcelo Sobral ^{[1
]}

Tavares, Josean Fechine ^{[1
]}

机构：

[1] Univ Fed Paraiba, Pharmaceut Technol Lab, BR-58051900 Joao Pessoa, Paraiba, Brazil

[2] Fed Univ Sao Francisco Valley, BR-56306410 Petrolina, PE, Brazil

[3] State Univ Paraiba, Dept Pharm, BR-58100000 Campina Grande, PB, Brazil

来源：

MOLECULES | 2011年 / 16卷 / 08期

关键词：

Annonaceae; Anaxagorea dolichocarpa; azaphenanthrene alkaloid; antitumor activity; CONSTITUENTS; SAMPANGINE; ACETOGENINS; MURICATA;

D O I：

10.3390/molecules16087125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC50 of 18.97 and 10.95 mu g/mL, respectively.

引用

页码：7125 / 7131

页数：7

共 5 条

[1] TWO NEW AZAPHENANTHRENE ALKALOIDS FROM Anaxagorea dolichocarpa Sprague & Sandwith
Sales, Kaio A.
Pinheiro, Anderson A., V
Araujo, Diego I. A. F.
de Andrade, Rodrigo S.
Agra, Maria de Fatima
Sobral, Marianna, V
Magalhaes, Hemerson I. F.
de Sousa, Valgricia M.
Braz-Filho, Raimundo
da Silva, Marcelo S.
Tavares, Josean F.
QUIMICA NOVA, 2020, 43 (06): : 692 - 696
[2] Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)
Costa, Emmanoel Vilaca
Belem Pinheiro, Maria Lucia
Leao de Souza, Afonso Duarte
Barison, Andersson
Campos, Francinete Ramos
Valdez, Rodrigo Hinojosa
Ueda-Nakamura, Tania
Dias Filho, Benedito Prado
Nakamura, Celso Vataru
MOLECULES, 2011, 16 (11) : 9714 - 9720
[3] Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)
Malebo, Hamisi M.
Wenzler, Tanja
Cal, Monical
Swaleh, Sauda M.
Omolo, Maurice O.
Hassanali, Ahmed
Sequin, Urs
Haeussinger, Daniel
Dalsgaard, Petur
Hamburger, Matthias
Brun, Reto
Ndiege, Isaiah O.
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 13
[4] Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)
Hamisi M Malebo
Tanja Wenzler
Monical Cal
Sauda M Swaleh
Maurice O Omolo
Ahmed Hassanali
Urs Séquin
Daniel Häussinger
Petur Dalsgaard
Matthias Hamburger
Reto Brun
Isaiah O Ndiege
BMC Complementary and Alternative Medicine, 13
[5] Dereplication of Aporphine Alkaloids by UHPLC-HR-ESI-MS/MS and NMR from Duguetia lanceolata St.-Hit (Annonaceae) and Antiparasitic Activity Evaluation
Dantas, Erick P.
Monteiro, Jackson
de Medeiros, Livia S.
Romanelli, Maiara M.
Amaral, Maiara
Tempone, Andre G.
Lago, Joao Henrique G.
Soares, Marisi G.
Sartorelli, Patricia
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2020, 31 (09) : 1908 - 1916

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