ELECTRICAL IMPEDANCE MYOGRAPHY IN FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY

被引:19
|
作者
Statland, Jeffrey M. [1 ]
Heatwole, Chad [2 ]
Eichinger, Katy [2 ]
Dilek, Nuran [2 ]
Martens, William B. [2 ]
Tawil, Rabi [2 ]
机构
[1] Univ Kansas, Med Ctr, Dept Neurol, 4330 Shawnee Mission Pkwy,Ste 323, Fairway, KS 66205 USA
[2] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA
基金
美国国家卫生研究院;
关键词
electrical impedance myography; facioscapulohumeral muscular dystrophy; muscle composition; muscular dystrophy; outcome measure; 6-MINUTE WALK TEST; RELIABILITY; PROGRESSION; ATROPHY;
D O I
10.1002/mus.25065
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: In this study we determined the reliability and validity of electrical impedance myography (EIM) in facioscapulohumeral muscular dystrophy (FSHD). Methods: We performed a prospective study of EIM on 16 bilateral limb and trunk muscles in 35 genetically defined and clinically affected FSHD patients (reliability testing on 18 patients). Summary scores based on body region were derived. Reactance and phase (50 and 100 kHZ) were compared with measures of strength, FSHD disease severity, and functional outcomes. Results: Participants were mostly men, mean age 53.0 years, and included a full range of severity. Limb and trunk muscles showed good to excellent reliability [ intraclass correlation coefficients (ICC) 0.72-0.99]. Summary scores for the arm, leg, and trunk showed excellent reliability (ICC 0.89-0.98). Reactance was the most sensitive EIM parameter to a broad range of FSHD disease metrics. Conclusions: EIM is a reliable measure of muscle composition in FSHD that offers the possibility to serially evaluate affected muscles.
引用
收藏
页码:696 / 701
页数:6
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