Metabolic Syndrome and Cognitive Decline Among the Oldest Old in Okinawa: In Search of a Mechanism. The KOCOA Project

被引：45

作者：

Katsumata, Yuriko ^{[1
,2
,3
]}

Todoriki, Hidemi ^{[2
]}

Higashiuesato, Yasushi ^{[4
]}

Yasura, Shotoku ^{[5
]}

Willcox, D. Craig ^{[5
,6
]}

Ohya, Yusuke ^{[7
]}

Willcox, Bradley J. ^{[6
,8
]}

Dodge, Hiroko H. ^{[3
]}

机构：

[1] Univ Ryukyus Hosp, Ctr Residency & Fellowship Program, Nishihara, Okinawa 9030215, Japan

[2] Univ Ryukyus, Dept Publ Hlth & Hyg, Grad Sch Med, Nishihara, Okinawa 90301, Japan

[3] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[4] Univ Ryukyus Hosp, Clin Labs, Nishihara, Okinawa 9030215, Japan

[5] Okinawa Int Univ, Dept Human Welf, Okinawa, Japan

[6] Kuakini Med Ctr, Dept Res, Honolulu, HI USA

[7] Univ Ryukyus, Dept Cardiovasc Med Nephrol & Neurol, Grad Sch Med, Nishihara, Okinawa 90301, Japan

[8] Univ Hawaii, John A Burns Sch Med, Dept Geriatr Med, Honolulu, HI 96822 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2012年 / 67卷 / 02期

关键词：

Metabolic syndrome; Cognitive decline; Oldest old; Longitudinal study; Okinawa; VASCULAR RISK-FACTORS; CEREBRAL-BLOOD-FLOW; MINI-MENTAL-STATE; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; DIABETES-MELLITUS; DEMENTIA; POPULATION; PRESSURE; LIFE;

D O I：

10.1093/gerona/glr189

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The study aim was to test whether the metabolic syndrome or its components predicted cognitive decline among persons aged 80 years and older (mean 85.0 years). Participants were members of the "Keys to Optimal Cognitive Aging Project," a prospective cohort study in Okinawa, Japan. Metabolic syndrome was assessed at baseline. Cognitive functions were assessed annually for up to 3 years. One hundred and forty-eight participants completed at least one follow-up with 101 participating in all three assessments and 47 participating in two of the three assessments. The mean and median duration of follow-up were 1.8 and 2 years, respectively. Metabolic syndrome and four components were not associated with decline in global and executive cognitive functions. However, high glycosylated hemoglobin was associated with decline in memory function at the second follow-up. Our study supports accumulating evidence that the positive association between metabolic syndrome and cognitive function might not hold for the oldest old.

引用

页码：126 / 134

页数：9

共 73 条

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