Direct carboxamidation of indoles by palladium-catalyzed C-H activation and isocyanide insertion

被引：102
|
作者：
Peng, Jiangling [1 ,2 ]
Liu, Lanying [1 ,2 ]
Hu, Ziwei [1 ,2 ]
Huang, Jinbo [1 ,2 ]
Zhu, Qiang [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Biomed, 190 Kaiyuan Ave, Guangzhou 510530, Guangdong, Peoples R China
[2] Chinese Acad Sci, State Key Lab Resp Dis, Guangzhou Inst Hlth, Guangzhou 510530, Guangdong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 31期
基金：
美国国家科学基金会;
关键词：
FUNCTIONALIZATION; AMIDATION; MILD; 4-AMINOQUINAZOLINES; ALKENYLATION; HETEROARENES; ANNULATION; CYANATION; BONDS;
D O I：
10.1039/c2cc30351e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A selective C3 carboxamidation of indoles including free (N-H) ones by palladium-catalyzed sequential C-H activation-isocyanide insertion has been developed.
引用
收藏
页码：3772 / 3774
页数：3
相关论文
共 50 条
  • [1] Palladium-catalyzed direct C-H allylation of indoles derivatives with allyltrimethylsilanes
    Wang, Lun
    He, Yuanhao
    Li, Zhi
    Zhang, Linchun
    Fan, Baoming
    Zhao, Fen
    Chen, Minghong
    TETRAHEDRON LETTERS, 2023, 129
  • [2] Dearomatization of Indoles via Palladium-Catalyzed Allylic C-H Activation
    Zhang, Heng
    Hu, Rong-Bin
    Liu, Na
    Li, Shi-Xia
    Yang, Shang-Dong
    ORGANIC LETTERS, 2016, 18 (01) : 28 - 31
  • [3] Direct Access to Isoindolinone Derivatives by Palladium-Catalyzed C-H Activation and Isocyanide Insertion by Using Molecular Oxygen as the Sole Oxidant
    Wang, Dongqi
    Cai, Sheng
    Ben, Rong
    Zhou, Yang
    Li, Xingwei
    Zhao, Jing
    Wei, Wei
    Qian, Yong
    SYNTHESIS-STUTTGART, 2014, 46 (15): : 2045 - 2050
  • [4] Palladium-Catalyzed Direct C-H Functionalization of Indoles with the Insertion of Sulfur Dioxide: Synthesis of 2-Sulfonated Indoles
    Liu, Tong
    Zhou, Wei
    Wu, Jie
    ORGANIC LETTERS, 2017, 19 (24) : 6638 - 6641
  • [5] Divergent isoindolinone synthesis through palladium-catalyzed isocyanide C-H activation
    Zhang, Fulin
    Zhao, Ruihua
    Zhu, Lei
    Yu, Yinghua
    Liao, Saihu
    Wang, Zhi-Xiang
    Huang, Xueliang
    CELL REPORTS PHYSICAL SCIENCE, 2022, 3 (03):
  • [6] Synthesis of 4-aminoquinolines by aerobic oxidative palladium-catalyzed double C-H activation and isocyanide insertion
    Vlaar, T.
    Maes, B. U. W.
    Ruijter, E.
    Orru, R. V. A.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2013, 49 (06) : 902 - 908
  • [7] Palladium-Catalyzed Sequential C-H Activation/Amination with Diaziridinone: An Approach to Indoles
    Li, Jing
    Chen, Jinhua
    Wang, Luying
    Shi, Yian
    ORGANIC LETTERS, 2021, 23 (09) : 3646 - 3651
  • [8] Synthesis of indoles, indolines, and carbazoles via palladium-catalyzed C-H activation
    Rago, Alexander J.
    Dong, Guangbin
    GREEN SYNTHESIS AND CATALYSIS, 2021, 2 (02): : 216 - 227
  • [9] Palladium-catalyzed direct sulfonylation of C-H bonds with the insertion of sulfur dioxide
    Xia, Hongguang
    An, Yuanyuan
    Zeng, Xincheng
    Wu, Jie
    CHEMICAL COMMUNICATIONS, 2017, 53 (93) : 12548 - 12551
  • [10] Palladium-Catalyzed Spirocyclization through C-H Activation and Regioselective Alkyne Insertion
    Yoon, Hyung
    Rolz, Martin
    Landau, Felicitas
    Lautens, Mark
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (36) : 10920 - 10923
12345