To address problems in cold chain logistics of agricultural products, the paper identifies the key risk factors affecting the operation of agricultural products cold chain logistics by the Delphi method, and then makes a quantitative study on the interrelationship among the risk factors by the TISM-MICMAC model. The results show that there is a heterogeneous relationship among risk factors, and there are significant differences in the effects of different risk factors on logistics operations; according to the criteria of driving force and dependence, risk factors can be divided into three types, which will determine different measures to control the risks in cold chain logistics of agricultural products.