Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line

被引：40
作者：
Chen, Xiao-ping [2 ]
Qian, Lin-lin [2 ]
Jiang, Hong [1 ]
Chen, Jiang-hua [1 ]
机构：
[1] Zhejiang Univ, Kidney Dis Ctr, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Coll Biol & Environm Engn, Hangzhou 310014, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY | 2011年 / 16卷 / 05期
关键词：
Keywords Rg3; Breast cancer; CXCR4; Mobility; Chemotaxis; CHEMOKINE RECEPTOR; IN-VITRO; METASTASIS; ANTAGONIST; RG(3); PROLIFERATION; PHARMACOLOGY; MOTILITY; INVASION; AMD3100;
D O I：
10.1007/s10147-011-0222-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Ginsenoside Rg3 is an extract from the natural product ginseng. Previous studies have linked Rg3 with anti-metastasis of cancer in vivo and in vitro. CXC receptor 4 (CXCR4) is a vital molecule in migration and homing of cancer to the docking regions. Methods In this study, the effects of Rg3 on CXCR4 expression were investigated in a breast cancer cell line. Immunohistochemistry, chemotaxis and wound healing mobility assays were performed in cultured MDA-MB-231 cells. Results At a dosage without obvious cytotoxicity, Rg3 treatment elicits a weak CXCR4 stain color, decreases the number of migrated cells in CXCL12-elicited chemotaxis and reduces the width of the scar in wound healing. Conclusion This work suggests that Rg3 is a new CXCR4 inhibitor from a natural product.
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收藏
页码：519 / 523
页数：5
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