Aging and osteoarthritis: Central role of the extracellular matrix

被引：385

作者：

Rahmati, Maryam ^{[1
,2
]}

Nalesso, Giovanna ^{[3
]}

Mobasheri, Ali ^{[4
,5
,6
,7
,8
]}

Mozafari, Masoud ^{[1
,2
,9
]}

机构：

[1] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran

[2] Iran Univ Med Sci, Fac Adv Technol Med, Dept Tissue Engn & Regenerat Med, Tehran, Iran

[3] Univ Surrey, Dept Vet Preclin Sci, Sch Vet Med, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England

[4] Univ Surrey, D BOARD European Consortium Biomarker Discovery, APPROACH Innovat Med Initiat IMI Consortium, Sch Vet Med,Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England

[5] Univ Nottingham, Arthrit Res UK Ctr Sport Exercise & Osteoarthriti, Arthrit Res UK Pain Ctr, Med Res Council,Queens Med Ctr, Nottingham NG7 2UH, England

[6] Univ Nottingham, Arthrit Res UK Ctr Musculoskeletal Ageing Res, Queens Med Ctr, Nottingham NG7 2UH, England

[7] King Abdulaziz Univ, CEGMR, KFMRC, Jeddah 21589, Saudi Arabia

[8] King Abdulaziz Univ, Sheik Salem Bin Mahfouz Sci Chair Treatment Osteo, Jeddah 21589, Saudi Arabia

[9] MERC, Bioengn Res Grp, Nanotechnol & Adv Mat Dept, POB 14155-4777, Tehran, Iran

来源：

AGEING RESEARCH REVIEWS | 2017年 / 40卷

关键词：

Osteoarthritis; Articular cartilage; Aging; Inflammatory mediators; Extracellular matrix; Chondrocyte; HUMAN ARTICULAR-CARTILAGE; GLYCATION END-PRODUCTS; CHROMATIN PROTEIN HMGB2; SUPEROXIDE-DISMUTASE; AGE-RELATED-CHANGES; OXIDATIVE STRESS; KNEE OSTEOARTHRITIS; CELLULAR SENESCENCE; SYNOVIAL-FLUID; POSTTRAUMATIC OSTEOARTHRITIS;

D O I：

10.1016/j.arr.2017.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life impairment in the aging population across the developed and developing world. Increased catabolism in the extracellular matrix (ECM) of the articular cartilage is a key factor in the development and progression of OA. The molecular mechanisms leading to an impaired matrix turnover have not been fully clarified, however cellular senescence, increased expression of inflammatory mediators as well as oxidative stress in association with an inherently limited regenerative potential of the tissue, are all important contributors to OA development. All these factors are linked to and tend to be maximized by aging. Nonetheless the role of aging in compromising joint stability and function in OA has not been completely clarified yet. This review will systematically analyze cellular and structural changes taking place in the articular cartilage and bone in the pathogenesis of OA which are linked to aging. A particular emphasis will be placed on age-related changes in the phenotype of the articular chondrocytes. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：20 / 30

页数：11

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