Plasmodium falciparum: DNA sequence specificity of cisplatin and cisplatin analogues

被引：5
|
作者：
Murray, Vincent [1 ]
Campbell, Heather M. [1 ]
Gero, Annette M. [1 ]
机构：
[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
来源：
EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 04期
基金：
英国医学研究理事会;
关键词：
Malaria; Transplatin; Carboplatin; Repeat sequence; DNA-targeted analogues; PLATINUM COMPLEXES; MALARIA; CIS-DIAMMINEDICHLOROPLATINUM(II); AGENTS; CARBOPLATIN; COMBINATION; DERIVATIVES; SELECTIVITY; POLYMERASE; RESISTANCE;
D O I：
10.1016/j.exppara.2011.05.002
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
In this paper, we provided evidence that cisplatin is able to form adducts with cellular DNA in Plasmodium falciparum. The DNA sequence specificity of cisplatin adduct formation was determined in trophozoite-enriched P. falciparum cells and this paper represents the first occasion that the sequence specificity of cisplatin DNA damage has been observed in malaria cells. Utilising a sub-telomeric, 692 bp repeat sequence in the P. falciparum genome, we were able to investigate the DNA adducts formed by cisplatin and five analogues. A run of eight consecutive guanines was the most prominent site of DNA damage in the malarial cells. This study suggests that the mechanism of P. falciparum cell death caused by cisplatin involves damage to DNA and hence inhibition of DNA replication and cell division. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：396 / 400
页数：5
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