Plasmodium falciparum: DNA sequence specificity of cisplatin and cisplatin analogues

被引：5

作者：

Murray, Vincent ^{[1
]}

Campbell, Heather M. ^{[1
]}

Gero, Annette M. ^{[1
]}

机构：

[1] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

来源：

EXPERIMENTAL PARASITOLOGY | 2011年 / 128卷 / 04期

基金：

英国医学研究理事会;

关键词：

Malaria; Transplatin; Carboplatin; Repeat sequence; DNA-targeted analogues; PLATINUM COMPLEXES; MALARIA; CIS-DIAMMINEDICHLOROPLATINUM(II); AGENTS; CARBOPLATIN; COMBINATION; DERIVATIVES; SELECTIVITY; POLYMERASE; RESISTANCE;

D O I：

10.1016/j.exppara.2011.05.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In this paper, we provided evidence that cisplatin is able to form adducts with cellular DNA in Plasmodium falciparum. The DNA sequence specificity of cisplatin adduct formation was determined in trophozoite-enriched P. falciparum cells and this paper represents the first occasion that the sequence specificity of cisplatin DNA damage has been observed in malaria cells. Utilising a sub-telomeric, 692 bp repeat sequence in the P. falciparum genome, we were able to investigate the DNA adducts formed by cisplatin and five analogues. A run of eight consecutive guanines was the most prominent site of DNA damage in the malarial cells. This study suggests that the mechanism of P. falciparum cell death caused by cisplatin involves damage to DNA and hence inhibition of DNA replication and cell division. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：396 / 400

页数：5

共 37 条

[1]

Boulikas T, 2004, ONCOL REP, V11, P559

[2] ISOLATION AND CHARACTERIZATION OF HUMAN CDNA CLONES ENCODING A HIGH MOBILITY GROUP BOX PROTEIN THAT RECOGNIZES STRUCTURAL DISTORTIONS TO DNA CAUSED BY BINDING OF THE ANTICANCER AGENT CISPLATIN [J].

BRUHN, SL ;

PIL, PM ;

ESSIGMANN, JM ;

HOUSMAN, DE ;

LIPPARD, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2307-2311

[3] The DNA sequence selectivity of maltolato-containing cisplatin analogues in purified plasmid DNA and in intact human cells [J].

Cairns, Murray J. ;

Carland, Michael ;

McFadyen, W. David ;

Denny, William A. ;

Murray, Vincent .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2009, 103 (08) :1151-1155

[4] A SIMPLE METHOD FOR ISOLATING VIABLE MATURE PARASITES OF PLASMODIUM-FALCIPARUM FROM CULTURES [J].

DLUZEWSKI, AR ;

LING, IT ;

RANGACHARI, K ;

BATES, PA ;

WILSON, RJM .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1984, 78 (05) :622-624

[5] Artemisinin resistance: current status and scenarios for containment [J].

Dondorp, Arjen M. ;

Yeung, Shunmay ;

White, Lisa ;

Nguon, Chea ;

Day, Nicholas P. J. ;

Socheat, Duong ;

von Seidlein, Lorenz .

NATURE REVIEWS MICROBIOLOGY, 2010, 8 (04) :272-280

[6] ADDUCTS OF THE ANTITUMOR DRUG CIS-DIAMMINEDICHLOROPLATINUM(II) WITH DNA - FORMATION, IDENTIFICATION, AND QUANTITATION [J].

FICHTINGERSCHEPMAN, AMJ ;

VANDERVEER, JL ;

DENHARTOG, JHJ ;

LOHMAN, PHM ;

REEDIJK, J .

BIOCHEMISTRY, 1985, 24 (03) :707-713

[7] Genome sequence of the human malaria parasite Plasmodium falciparum [J].

Gardner, MJ ;

Hall, N ;

Fung, E ;

White, O ;

Berriman, M ;

Hyman, RW ;

Carlton, JM ;

Pain, A ;

Nelson, KE ;

Bowman, S ;

Paulsen, IT ;

James, K ;

Eisen, JA ;

Rutherford, K ;

Salzberg, SL ;

Craig, A ;

Kyes, S ;

Chan, MS ;

Nene, V ;

Shallom, SJ ;

Suh, B ;

Peterson, J ;

Angiuoli, S ;

Pertea, M ;

Allen, J ;

Selengut, J ;

Haft, D ;

Mather, MW ;

Vaidya, AB ;

Martin, DMA ;

Fairlamb, AH ;

Fraunholz, MJ ;

Roos, DS ;

Ralph, SA ;

McFadden, GI ;

Cummings, LM ;

Subramanian, GM ;

Mungall, C ;

Venter, JC ;

Carucci, DJ ;

Hoffman, SL ;

Newbold, C ;

Davis, RW ;

Fraser, CM ;

Barrell, B .

NATURE, 2002, 419 (6906) :498-511

[8] Artemisinin derivatives for treatment of uncomplicated Plasmodium falciparum malaria in Sudan: too early for too much hope [J].

Giha, Hayder A. .

PARASITOLOGY RESEARCH, 2010, 106 (03) :549-552

[9] How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance [J].

Hastings, Ian .

TRENDS IN PARASITOLOGY, 2011, 27 (02) :67-72

[10] cis-dichloroplatinum(II) complexes tethered to 9-aminoacridine-4-arboxamides:: synthesis and action in resistant cell lines in vitro [J].

Holmes, RJ ;

McKeage, MJ ;

Murray, V ;

Denny, WA ;

McFadyen, WD .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2001, 85 (2-3) :209-217

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