Cutaneous dendritic cells

被引：206

作者：

Valladeau, J

Saeland, S

机构：

[1] Univ Lyon 1, Hop Edouard Herriot, F-69437 Lyon, France

[2] INSERM, U503, IFR128, F-69373 Lyon, France

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 04期

关键词：

Langerhans cells; dermal dendritic cells; skin; antigen capture; dendritic cell migration;

D O I：

10.1016/j.smim.2005.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cutaneous dendritic cells (DC) include epidermal Langerhans cells (LC), interstitial/dermal dendritic cells (DDC), as well as plasmacytoid DC (pDC) that occur Linder pathological conditions. These immune cells have a spectrum of different functions with implications that extend far beyond the skin. They have the potential to internalize particulate agents and macromolecules, and display migratory properties that endow them with the unique capacity to journey between skin and draining lymph nodes where they encounter antigen-specific T lymphocytes. Herein, we will review the features of human and Mouse cutaneous DC, emphasizing characteristics representative of their life-cycle stages that occur within the skin. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：273 / 283

页数：11

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