Calcium ionophore A 23187 induces apoptotic cell death in rat thymocytes

被引：16
作者：
Azmi, S [1 ]
Dhawan, D [1 ]
Singh, N [1 ]
机构：
[1] ALL INDIA INST MED SCI,DEPT BIOCHEM,NEW DELHI 110029,INDIA
来源：
CANCER LETTERS | 1996年 / 107卷 / 01期
关键词：
calcium ionophore A 23187; apoptosis; poly ADPR polymerase; thymocytes; genes;
D O I：
10.1016/0304-3835(96)04349-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Apoptotic cell death was induced in rat thymocytes on exposure to calcium ionophore A 23187 (100 mu m) for 24 h as observed from morphological changes and DNA fragmentation into oligonucleosomal ladder. The cell death was independent of de novo syntheses of protein. However, the involvement of c-Myc, c-Jun, poly ADPR polymerase and antioxidant enzymes CuZn SOD and catalase was observed.
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页码：97 / 103
页数：7
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