Flavonoids as cycline-dependent kinase inhibitors: Inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series

被引：30
作者：
Aligiannis, N
Mitaku, S [1 ]
Mitrocotsa, D
Leclerc, S
机构：
[1] Univ Athens, Sch Pharm, Div Pharmacognosy, Dept Pharm, GR-15771 Athens, Greece
[2] CNRS, Biol Stn, Roscoff, France
来源：
PLANTA MEDICA | 2001年 / 67卷 / 05期
关键词：
D O I：
10.1055/s-2001-15807
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In an effort to detect potential inhibitors of cdc25 phosphatase, nineteen flavonoids belonging to the quercetin and kaempferol series have been evaluated, using a colorimetric assay of recombinant human cdc25A tyrosine phosphatase as a cell cycle-specific target. Compounds bearing two benzyl or methyl groups in positions 7 and 4 ' and acetyl on the hydroxy groups of the sugar moiety showed the maximal activity.
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收藏
页码：468 / 470
页数：3
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