Pediatric Venous and Arterial Noncerebral Thromboembolism in Denmark: A Nationwide Population-Based Study

被引:79
作者
Tuckuviene, Ruta [1 ,2 ]
Christensen, Anette L.
Helgestad, Jon [2 ]
Johnsen, Soren P. [3 ,4 ]
Kristensen, Soren R.
机构
[1] Aalborg Hosp, Dept Clin Biochem, Aarhus Univ Hosp, Cardiovasc Res Ctr, DK-9000 Aalborg, Denmark
[2] Aalborg Hosp, Aarhus Univ Hosp, Dept Pediat, DK-9000 Aalborg, Denmark
[3] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark
[4] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark
关键词
RISK-FACTORS; CHILDREN; THROMBOSIS; CHILDHOOD; THROMBOPHILIA; MUTATION; REGISTRY; DISEASE; COHORT;
D O I
10.1016/j.jpeds.2011.03.052
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To assess the incidence rate (IR), changes in IR over time, risk factors, treatment, and outcomes of pediatric noncerebral thromboembolism (TE). Study design The study included all patients aged 0 to 18 years diagnosed with first-ever noncerebral venous thromboembolism (VTE) and/or arterial TE in Denmark between 1994 and 2006. Patients were identified in national registries, followed by validation of diagnoses by medical records review. Results We confirmed 331 cases of VTE and 46 cases of arterial TE during 15.8 million person-years of observation, with corresponding IRs of 2.09 and 0.29 per 100 000 person-years. The IR peaked in infancy (age <1 year) for both VTE and arterial TE, with an additional peak among adolescents (age 15 to 18 years) for VTE. Boys predominated in IR of VTE in infancy, whereas girls did so in adolescence (P < .01). The IRs of VTE and arterial TE remained stable during the study period, but with an trend toward increasing VTE in 2001 to 2006 (P = .064). Underlying diseases/external triggers were present in 86.6% of the patients, and thrombophilia was present in 47.9% of the VTE cases. All-cause and TE-related 30-day case fatalities were 4.0% and 1.6%, respectively. Conclusions We found age- and sex-related disparities in the IRs of pediatric VTE and arterial TE, but insignificant changes in IR from 1994 to 2006. (J Pediatr 2011;159:663-9).
引用
收藏
页码:663 / 669
页数:7
相关论文
共 21 条
[1]  
Andersen TF, 1999, DAN MED BULL, V46, P263
[2]   VENOUS THROMBOEMBOLIC COMPLICATIONS (VTE) IN CHILDREN - FIRST ANALYSES OF THE CANADIAN REGISTRY OF VTE [J].
ANDREW, M ;
DAVID, M ;
ADAMS, M ;
ALI, K ;
ANDERSON, R ;
BARNARD, D ;
BERNSTEIN, M ;
BRISSON, L ;
CAIRNEY, B ;
DESAI, D ;
GRANT, R ;
ISRAELS, S ;
JARDINE, L ;
LUKE, B ;
MASSICOTTE, P ;
SILVA, M .
BLOOD, 1994, 83 (05) :1251-1257
[3]   Epidemiology of venous thromboembolism in neonates and children [J].
Chalmers, Elizabeth A. .
THROMBOSIS RESEARCH, 2006, 118 (01) :3-12
[4]   How well protected are sexually active 15-year olds? Cross-national patterns in condom and contraceptive pill use 2002-2006 [J].
Gabhainn, Saoirse Nic ;
Baban, Adriana ;
Boyce, William ;
Godeau, Emmanuelle .
INTERNATIONAL JOURNAL OF PUBLIC HEALTH, 2009, 54 :209-215
[5]   Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors [J].
Goldenberg, Neil A. ;
Donadini, Marco R. ;
Kahn, Susan R. ;
Crowther, Mark ;
Kenet, Gili ;
Nowak-Goettl, Ulrike ;
Manco-Johnson, Marilyn J. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (11) :1952-1959
[6]   Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia [J].
Junker, R ;
Koch, HG ;
Auberger, K ;
Münchow, N ;
Ehrenforth, S ;
Nowak-Göttl, U .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (10) :2568-2572
[7]   The Arg506Gln mutation (FV Leiden) among a cohort of 4188 unselected Danish newborns [J].
Larsen, TB ;
Lassen, JF ;
Brandslund, I ;
Byriel, L ;
Petersen, GB ;
Norgaard-Pedersen, B .
THROMBOSIS RESEARCH, 1998, 89 (05) :211-215
[8]   Neonatal renal vein thrombosis: Review of the english-language literature between 1992 and 2006 [J].
Lau, Keith K. ;
Stoffman, Jayson M. ;
Williams, Suzane ;
McCusker, Patricia ;
Brandao, Leonardo ;
Patel, Sanjay ;
Chan, Anthony K. C. .
PEDIATRICS, 2007, 120 (05) :E1278-E1284
[9]   Hormonal contraception and risk of venous thromboembolism: national follow-up study [J].
Lidegaard, Ojvind ;
Lokkegaard, Ellen ;
Svendsen, Anne Louise ;
Agger, Carsten .
BRITISH MEDICAL JOURNAL, 2009, 339 :557-560
[10]   Outcome of pediatric thromboembolic disease: A report from the Canadian Childhood Thrombophilia Registry [J].
Monagle, P ;
Adams, M ;
Mahoney, M ;
Ali, K ;
Barnard, D ;
Bernstein, M ;
Brisson, L ;
David, M ;
Desai, S ;
Scully, MF ;
Halton, J ;
Israels, S ;
Jardine, L ;
Leaker, M ;
McCusker, P ;
Silva, M ;
Wu, J ;
Anderson, R ;
Andrew, M ;
Massicotte, MP .
PEDIATRIC RESEARCH, 2000, 47 (06) :763-766