Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia -: A replication study

被引：33

作者：

Juckel, Georg ^{[1
,2
]}

Gudlowski, Yehonala ^{[3
]}

Mueller, Dirk ^{[2
]}

Oezguerdal, Seza ^{[1
]}

Bruene, Martin ^{[1
]}

Gallinat, Juergen ^{[3
]}

Frodl, Thomas ^{[2
]}

Witthaus, Henning ^{[1
]}

Uhl, Idun ^{[1
]}

Wutzler, Alexander ^{[3
]}

Pogarell, Oliver ^{[2
]}

Mulert, Christoph ^{[2
]}

Hegerl, Ulrich ^{[2
]}

Meisenzahl, Eva-Maria ^{[2
]}

机构：

[1] Ruhr Univ Bochum, Med Clin, Westphalian Ctr Bochum Psychiat Psychotherapy Psy, Dept Psychiat Psychotherapy & Psychosomat Med, D-44791 Bochum, Germany

[2] Univ Munich, Dept Psychiat & Psychotherapy, D-80539 Munich, Germany

[3] Charite, Dept Psychiat, Berlin, Germany

来源：

PSYCHIATRY RESEARCH | 2008年 / 158卷 / 01期

关键词：

scrotonin; schizophrenia; auditory evoked potentials; loudness dependence;

D O I：

10.1016/j.psychres.2007.08.013

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Serotonergic dysfunction appears to be involved in the pathogenesis of schizophrenia. The loudness dependence of auditory evoked potentials (LDAEP) has been Suggested to be a valid indicator of the brain serotonin system's activity in humans. Patients with schizophrenia showed weaker LDAEP, indicating high scrotonergic activity, in comparison to healthy controls. Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：79 / 82

页数：4

共 16 条

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