Workflow to improve patient recruitment for clinical trials within hospital information systems -: a case-study

被引：37

作者：

Dugas, Martin ^{[1
]}

Lange, Matthias ^{[2
]}

Berdel, Wolfgang E. ^{[3
]}

Mueller-Tidow, Carsten ^{[3
]}

机构：

[1] Univ Munster, Dept Med Informat & Biomath, D-48149 Munster, Germany

[2] Univ Klinikum Munster, IT Ctr, D-48149 Munster, Germany

[3] Univ Klinikum Munster, Dept Med A, D-48149 Munster, Germany

来源：

TRIALS | 2008年 / 9卷 / 1期

关键词：

D O I：

10.1186/1745-6215-9-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: The identification of suitable patients is a common problem in clinical trials that is especially evident in tertiary care hospitals. Methods: We developed and analysed a workflow, which uses routine data captured during patient care in a hospital information system ( HIS), to identify potential trial subjects. Study nurses or physicians are notified automatically by email and verify eligibility. Results: As a case study we implemented the system for acute myeloid leukemia (AML) trials in Munster. During a test period of 50 days 41 patients were identified by the system. 13 could be included as new trial patients, 7 were already included during earlier visits. According to review of paper records no AML trial patient was missed by the system. In addition, the hospital information system further allowed to preselect patients for specific trials based on their disease status and individual characteristics. Conclusion: Routine HIS data can be used to support patient recruitment for clinical trials by means of an automated notification workflow.

引用

页数：6

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