Impact of Genetic and Nongenetic Factors on Body Mass Index and Waist-Hip Ratio Change in HIV-Infected Individuals Initiating Antiretroviral Therapy

被引：11

作者：

Barcelo, Catalina ^{[1
]}

Guidi, Monia ^{[1
,2
,3
]}

Thorball, Christian W. ^{[4
,5
]}

Hammer, Christian ^{[6
,7
]}

Chaouch, Aziz ^{[2
,3
]}

Scherrer, Alexandra U. ^{[8
]}

Hasse, Barbara ^{[9
]}

Cavassini, Matthias ^{[3
,10
]}

Furrer, Hansjakob ^{[11
]}

Calmy, Alexandra ^{[12
,13
]}

Haubitz, Sebastian ^{[14
]}

Bernasconi, Enos ^{[15
]}

Buclin, Thierry ^{[2
,3
]}

Fellay, Jacques ^{[3
,4
,5
,16
]}

Tarr, Philip E. ^{[17
]}

Csajka, Chantal ^{[1
,18
]}

机构：

[1] Univ Lausanne, Inst Pharmaceut Sci Western Switzerland, Ctr Res & Innovat Clin Pharmaceut Sci, Lausanne, Switzerland

[2] Lausanne Univ Hosp, Serv Clin Pharmacol, Lausanne, Switzerland

[3] Univ Lausanne, Lausanne, Switzerland

[4] Ecole Polytech Fed Lausanne, Sch Life Sci, Lausanne, Switzerland

[5] Swiss Inst Bioinformat, Lausanne, Switzerland

[6] Genentech Inc, Dept Canc Immunol, San Francisco, CA USA

[7] Genentech Inc, Dept Human Genet, San Francisco, CA USA

[8] Univ Zurich, Inst Med Virol, Zurich, Switzerland

[9] Univ Zurich, Univ Hosp Zurich, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland

[10] Lausanne Univ Hosp, Serv Infect Dis, Lausanne, Switzerland

[11] Univ Bern, Bern Univ Hosp, Dept Infect Dis, Bern, Switzerland

[12] Univ Geneva, Geneva Univ Hosp, Div Infect Dis, HIV AIDS Unit, Geneva, Switzerland

[13] Univ Geneva, Fac Med, Geneva, Switzerland

[14] Kantonsspital Aarau, Dept Infect Dis & Hosp Hyg, Aarau, Switzerland

[15] Reg Hosp, Div Infect Dis, Lugano, Switzerland

[16] Lausanne Univ Hosp, Precis Med Unit, Lausanne, Switzerland

[17] Univ Basel, Kantonsspital Baselland, Univ Dept Med, Infect Dis Serv, Basel, Switzerland

[18] Univ Geneva, Inst Pharmaceut Sci Western Switzerland, Sch Pharmaceut Sci, Geneva, Switzerland

来源：

OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

abdominal obesity; antiretroviral therapy; body mass index; genetics; nadir CD4 cell count; obesity; waist-hip ratio; HUMAN-IMMUNODEFICIENCY-VIRUS; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR-DISEASE; WEIGHT-GAIN; METABOLIC SYNDROME; UNITED-STATES; FAT CHANGES; OBESITY; RISK; ASSOCIATION;

D O I：

10.1093/ofid/ofz464

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective. There is limited data on abdominal obesity and the influence of genetics on weight change after ant iretroviral therapy (ART) initiation. We assessed body mass index (BMI) and waist hip ration (WHR) change over time in the Swiss HIV Cohort study (SHCS). Methods. Mixed-effects models characterizing BMI and WHR change over time in 1090 SHCS participants initiating ART between 2005 and 2015 were developed and used to quantify the influence of demographics, clinical factors, and genetic background. Results. Individuals with CD4 nadir <100 cells/mu L, gained 6.4 times more BMI than individuals with >= 200, and 2.8 times more WHR than individuals with >= 100 (P < .001) during the first 1.5 and 2.5 years after ART initiation, respectively. The risk of being overweight or obese after 1.5 years increased with CD4 nadir <100 cells/mu L, compared to 100-199 (odds ratio [OR], 2.07; 95% confidence interval [CI], 1.63-2.74) and >= 200 (OR, 1.69; 95% CI, 1.26-2.32), persisting after 10 years of ART. The risk of abdominal obesity after 2.5 years increased with CD4 nadir <100 compared to >= 100 (OR, 1.35; 95% CI, 1.17-1.54 [in men]; OR, 1.36; 95% CI, 1.18-1.57 [in women]), persisting after 10 years of ART No significant differences were found across antiretroviral drug classes or genetic scores. Conclusions. The risk of general and abdominal obesity increased with CD4 nadir <100 cells/mu l. Based on our results, including the genetic background would not improve obesity predictions in HIV-infected individuals.

引用

页数：10

共 53 条

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