Epoxyeicosatrienoic acid: A potential therapeutic target of heart failure with preserved ejection fraction

被引：7

作者：

Zhang, Min ^{[1
,2
]}

Shu, Hongyang ^{[1
,2
]}

Chen, Chen ^{[1
,2
]}

He, Zuowen ^{[1
,2
]}

Zhou, Zhou ^{[1
,2
]}

Wang, Dao Wen ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med,Div Cardiol, Wuhan 430030, Peoples R China

[2] Hubei Key Lab Genet & Mol Mech Cardiol Disorders, Wuhan 430030, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 153卷

基金：

中国国家自然科学基金;

关键词：

Epoxyeicosatrienoic acid; Heart failure with preserved ejection fraction; Inflammation; Endothelial dysfunction; Cardiomyocyte remodeling; Fibrosis; SOLUBLE EPOXIDE HYDROLASE; DIASTOLIC DYSFUNCTION; DIABETIC CARDIOMYOPATHY; MYOCARDIAL STIFFNESS; CARDIAC-HYPERTROPHY; FATTY-ACID; EPOXYGENASE; CYP2J2; INFLAMMATION; EXPRESSION;

D O I：

10.1016/j.biopha.2022.113326

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Heart failure with preserved ejection fraction (HFpEF) reduces the quality of life, costs substantial medical resources, and has a high mortality. However, we lack an effective therapy for HFpEF due to our limited knowledge of its mechanism. Therefore, it is crucial to explore novel therapeutics, such as those with endogenous protective roles, and seek new targeted therapies. Epoxyeicosatrienoic acids (EETs) are endogenous bioactive metabolites of arachidonic acids produced by cytochrome P450 (CYP) epoxygenases. EETs can function as endogenous cardioprotective factors with potent inhibitory roles in inflammation, endothelial dysfunction, cardiac remodeling, and fibrosis, which are the fundamental mechanisms of HFpEF. This suggests that EETs have the potential function to protect against HFpEF. Therefore, we present an overview of the ever-expanding world of EETs and how they might help alleviate the pathophysiology underlying HFpEF to provide new insights for research in this field.

引用

页数：8

共 99 条

[21] Distribution of soluble epoxide hydrolase and of cytochrome P4502C8, 2C9, and 2J2 in human tissues [J].