Protective effect of Rhinax, a herbal formulation, against CCl4-induced liver injury and survival in rats

Rhinax, a herbal formulation, was investigated for its protective activity against CCl4-induced liver injury and survival in rats. Oral administration of Rhinax at a dose of 80 mg/kg significantly reduces the hepatotoxic effects of CCl4. It also significantly improves the survival of rats at a dose of 160 mg/kg. On the basis of these observations, we conclude that Rhinax possesses anti-hepatotoxic activity and that the observed activity may be due to the increased activity of cytochrome P450, thereby exerting an inhibitory effect on reductive pathways of CCl4. (C) 1997 Elsevier Science Ireland Ltd.