Progress in the Synthesis of Indole Alkaloid Uleine and Its Derivatives

被引：1

作者：

Wang, Xuejun ^{[1
,2
]}

Liu, Jianli ^{[1
]}

Huang, Xinwei ^{[1
]}

Wang, Cuiling ^{[1
]}

机构：

[1] NW Univ Xian, Sch Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Peoples R China

[2] Gansu Coll Tradit Chinese Med, Dept Chem, Lanzhou 730000, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 32卷 / 02期

基金：

中国国家自然科学基金;

关键词：

uleine; derivative; synthesis; review; FRAMEWORK; 2-CYANO-1,2,3,6-TETRAHYDROPYRIDINES; (+)-ULEINE; ROUTE;

D O I：

10.6023/cjoc1108212

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Uleine and its derivatives belong to the monoterpenoid indole alkaloids based on their structures. The characteristic of their structures is only one carbon atom which separates the indole nucleus and the basic nitrogen atom, as opposed to the normal two-carbon bridge of tryptamine and most monoterpenoid indole alkaloids. Their natural contents are extremely low, and their synthetic work has attracted generations of chemists. The synthetic methods of uleine and its derivatives are reviewed according to the types of structure building methodology. The indole and pyridine derivatives were used as the starting material in most tetracyclic synthesis. Several simple and convenient routes are succeeded.

引用

页码：420 / 430

页数：11

共 47 条

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