Particles, Pressure, and System Contribution: The Holy Trinity of Ultrahigh-Performance Liquid Chromatography

被引：0
作者：
Broeckhoven, Ken [1 ]
De Vos, Jelle [1 ]
Desmet, Gert [1 ]
机构：
[1] Vrije Univ Brussel, Dept Chem Engn, Brussels, Belgium
来源：
LC GC EUROPE | 2017年 / 30卷 / 11期
关键词：
KINETIC PERFORMANCE; POROUS PARTICLES; COLUMNS; SEPARATIONS; EFFICIENCY; UHPLC; TECHNOLOGY; RESOLUTION; IMPACT; FUTURE;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The last decade has witnessed how liquid chromatography columns and instruments changed from long,bulky columns with relatively large fully porous particles operated at modest pressures (100-200 bar), to short compact columns with small superficially porous particles operated at ultrahigh pressures (12001500 bar). This (r)evolution has resulted in a tremendous increase in achievable separation performance or decrease in analysis time, but requires a good knowledge of optimal chromatographic conditions for each separation problem and, concomitant, the right instrument configuration.
引用
收藏
页码：618 / 625
页数：8
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