Phorbol dibutyrate-induced megakaryocytic differentiation increases susceptibility of K562 cells to SA11 rotavirus infection

被引：1

作者：

Sanders, GM ^{[1
]}

Hewish, MJ ^{[1
]}

Coulson, BS ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

来源：

ARCHIVES OF VIROLOGY | 2001年 / 146卷 / 09期

关键词：

D O I：

10.1007/s007050170069

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of integrins previously implicated as rotavirus receptors in determining cellular susceptibility to SA11 rotavirus was studied, using phorbol dibutyrate (PDB) treatment of K562 cells to induce megakaryocytic differentiation. Expression of alpha2 beta1 integrin was detected after 2 days in PDB, and peaked after PDB treatment for 4-7 days. SA11 titres were increased by 1.8- to 10.8-fold over untreated cells after PDB treatment for 2-7 days, and correlated with levels of alpha2 beta1 integrin expression in PDB-treated K562 cells.

引用

页码：1831 / 1840

页数：10

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