Metal complexes of 2-benzoylpyridine-derived thiosemicarbazones:: structural, electrochemical and biological studies

被引：94
作者：
Costa, RFF
Rebolledo, AP
Matencio, T
Calado, HDR
Ardisson, JD
Cortés, ME
Rodrigues, BL
Beraldo, H [1 ]
机构：
[1] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil
[2] CDTN, Ctr Desenvolvimento Tecnol Nucl, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Fac Odontol, BR-31270901 Belo Horizonte, MG, Brazil
[4] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Paulo, Brazil
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2005年 / 58卷 / 15期
关键词：
2-benzoylpyridine thiosemicarbazones; metal complexes; biological activity;
D O I：
10.1080/00958970500213307
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Complexes of 2-benzoylpyridine thiosemicarbazone (H2Bz4DH) as well as of its N(4)-methyl (H2Bz4Me) and N(4)-phenyl (H2Bz4Ph) analogues with iron(II), nickel( II) and zinc( II) were characterized by a variety of spectroscopic techniques. Electrochemical studies revealed that the iron( II) complexes undergo oxidation giving the iron(III) analogues, which could be reduced back by cellular thiols such as thioredoxine, suggesting that this process could occur in biological media. The thiosemicarbazones have antifungal activity against Candida albicans that significantly decreases on coordination. The crystal structure 2-benzoylpyridine-N(4)- methyl thiosemicarbazone (H2Bz4Me) was determined.
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收藏
页码：1307 / 1319
页数：13
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