Chronic oxidative stress induces a tissue-specific reduction in telomere length in CAST/Ei mice

被引：94

作者：

Cattan, Valerie ^{[1
,2
]}

Mercier, Nathalie ^{[1
,2
]}

Gardner, Jeffrey P. ^{[3
]}

Regnault, Veronique ^{[2
,4
]}

Labat, Carlos ^{[1
,2
]}

Maki-Jouppila, Jenni ^{[1
,2
]}

Nzietchueng, Rosine ^{[1
,2
]}

Benetos, Athanase ^{[1
,2
]}

Kimura, Masayuki ^{[3
]}

Aviv, Abraham ^{[3
]}

Lacolley, Patrick ^{[1
,2
]}

机构：

[1] UHP Nancy, Fac Med, INSERM U684, F-54500 Vandoeuvre Les Nancy, France

[2] Henri Poincare Univ, F-54000 Nancy, France

[3] Univ Med & Dent New Jersey, Ctr Human Dev & Aging, New Jersey Med Sch, Newark, NJ 07103 USA

[4] INSERM U734, F-54500 Vandoeuvre Les Nancy, France

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2008年 / 44卷 / 08期

关键词：

telomere; mouse; tissue; oxidative stress; glutathione;

D O I：

10.1016/j.freeradbiomed.2008.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examine whether increased oxidative stress in vivo promotes telomere shortening in CAST/Ei mice. We explored the effects of L-buthionine sulfoximine treatment (BSO) on telomere length. BSO shortened telomere length in white fat, brown fat, skin, tail, and testis in concert with diminished tissue glutathione content, increased tissue carbonyl content, and increased plasma advanced oxidized protein products. Telomerase activity was mainly detected in testis but no reduction of telomerase activity was observed in response to BSO. In conclusion, BSO-mediated increase in systemic oxidative stress shortens telomeres in several tissues of the mouse. The variable effect of BSO treatment on telomere length in different tissue may result from their different adaptive antioxidative capacity. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：1592 / 1598

页数：7

共 34 条

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