Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II

被引：13
作者：
Gul, Halise Inci [1 ]
Yazici, Zehra [1 ]
Tanc, Muhammet [2 ,3 ]
Supuran, Claudiu T. [2 ,3 ]
机构：
[1] Ataturk Univ, Dept Pharmaceut Chem, Fac Pharm, Erzurum, Turkey
[2] Univ Florence, Neurofarba Dept, Florence, Italy
[3] Univ Florence, Lab Chim Bioinorgan, Via U Schiff 6, I-50019 Florence, Italy
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2016年 / 31卷 / 06期
关键词：
Benzimidazole; carbonic anhydrase; enzyme inhibition; Mannich bases; phenol; CORRESPONDING PIPERIDINOLS; CELLULAR GLUTATHIONE; JURKAT CELLS; CYTOTOXICITY; DERIVATIVES; HYDROCHLORIDES; ACTIVATORS; MECHANISM;
D O I：
10.3109/14756366.2016.1156675
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New phenolic mono and bis Mannich bases incorporating benzimidazole, such as 2-(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol and 2,6-bis(aminomethyl)-4-(1H-benzimidazol-2-yl)phenol were synthesized starting from 4-(1H-benzimidazol-2-yl)phenol. Amines used for the synthesis included dimethylamine, pyrrolidine, piperidine, N-methylpiperazine and morpholine. The CA inhibitory properties of these compounds were tested on the human carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I and hCA II. These new compounds, as many phenols show moderate CA inhibitory properties.
引用
收藏
页码：1540 / 1544
页数：5
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