The D-2 dopamine receptor gene as a determinant of reward deficiency syndrome

The dopaminergic system, and in particular the dopamine D-2 receptor, has been profoundly implicated in reward mechanisms in the brain, Dysfunction of the D-2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D-2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.